关键词: 哮喘, 身高, 肺通气功能, 呼出气一氧化氮

Abstract: Objective To observe the changes of pulmonary ventilation function, fractional exhaled nitric oxide (FeNO) and height in children with uncontrolled group and well-controllled group of moderate asthma. Methods Children with moderate asthma from January 2017 to June 2018 were collected, and were divided into uncontrolled asthma group (50 cases with intermittent use of ICS combined with Menglusite) and well-controlled group (50 cases with regular use of ICS combined with Menglusite). Meantime, 50 cases with non-asthmatic children were selected into the control group. After 6 months and 12 months of treatment, the uncontrolled group and the well-controlled group performed FEV1, PEF, and FeNO tests, and the height of three groups of children was measured. Results After 6 months and 12 months of treatment, FEV1 and PEF were significantly lower in uncontrolled group than those in well-controlled group (P<0.05). And FeNO in uncontrolled group did not decrease significantly and was higher than that in well-controlled group (P<0.05).After 12 months of treatment, the height of children in well-controlled group was not significantly different compared with that of the control group (P>0.05), while the height of children in the uncontrolled group was significantly lower than that of the control group (P<0.05). Conclusion Irregular use of drugs leads to poor asthma control, resulting in hyperractivity of airway and ventilation dysfunction, and is also an important factor affecting the height of children.

Key words: asthma, height, pulmonary ventilation function, fractional exhaled nitric oxide