关键词: 儿童, 哮喘急性发作, 危险因素, Meta分析, 母乳喂养, 过敏

Abstract: Objective To systematically evaluate the main risk factors for acute attack of asthma in Chinese children,and to provide basis for early prevention,treatment and improvement of prognosis of acute attack of asthma in children. Methods Databases of CNKI,Wanfang Data,VIP,Web of science,PubMed,Cochrane and Embase were searched to systematically collect literatures from the establishment to May 31st,2020 to study the risk factors of Chinese children's acute asthma attack.The data were screened and extracted by two persons independently for quality control,and the RevMan5.3 software provided by Cochrane was used for Meta-analysis. Results A total of 8 case-control studies were included in the qualitative analysis,of which 7 were evaluated quantitatively,including 1 170 cases in the case group and 882 cases in the control group.Meta-analysis showed that the main risk factors for acute attack of asthma in children included history of respiratory tract infection(OR=1.68,95%CI:1.20—2.35),history of passive smoking(OR=1.99,95%CI:1.47—2.69),family history of asthma(OR=2.11,95%CI:1.57—2.84),history of allergy in children(OR=3.84,95%CI:2.27—6.48)and unstandardized medication(OR=2.83,95%CI:1.69—4.75),while breastfeeding was a protective factor(OR=0.48,95%CI:0.31—0.72). Conclusions There are many risk factors for acute attack of asthma in Chinese children,among which the history of allergy is the primary risk factor,followed by unstandardized medication and family history of asthma,while breastfeeding can reduce the risk of acute attack of asthma in children.

Key words: children, acute attack of asthma, risk factors, Meta-analysis, breastfeeding, allergy