关键词: 维生素A, 免疫球蛋白, 反复呼吸道感染, 儿童

Abstract: Objective To analyze the relationship between serum vitamin A level and recurrent respiratory tract infection (RRTI) in children, so as to provide reference for the prediction of vitamin A as a risk of RRTI and the adjuvant treatment of RRTI. Methods A total of 120 children with RRTI admitted to the second pediatrics department of the Fourth Affiliated Hospital of China Medical University were selected as observation group from August 2017 to August 2018.And the other 120 children with respiratory infection admitted to the hospital in the same period were selected as the control group.The levels of vitamin A and immunoglobulin (IgA, IgG, IgM) in two groups were analyzed and compared.And the relationship between vitamin A and immunoglobulin was analyzed.Children with RRTI were followed up for one year, exogenous vitamin A supplementation was recorded after discharge, and the number of RRTI was observed. Results The serum vitamin A level of the observation group was lower than that of control group, and the detection rate of subclinical vitamin A deficiency in the observation group was higher than that of control group (t=2.632, χ²=7.366, P<0.05).The IgG level in the vitamin A deficiency group was significantly lower than that in children with normal vitamin A level (F=5.036, P＜0.05).Pearson analysis showed that vitamin A level was positively correlated with IgG level (r=0.172, P<0.05).There was no significant difference on the number of respiratory infections between the groups with vitamin A supplementation and without vitamin A supplementation before treatment (P>0.05).After treatment, the number of respiratory infection in both groups was significantly reduced (t=9.291, 2.036, P<0.05), and it was less in the group with vitamin A supplementation than group without vitamin A supplementation (t=2.448, P＜0.05). Conclusion RRTI is associated with vitamin A deficiency, and vitamin A supplementation can be helpful to reduce respiratory infection.

Key words: vitamin A, immunoglobulin, recurrent respiratory tract infection, children