关键词: 前囟, 延迟闭合, 婴幼儿

Abstract: Objective To explore the associated factors of anterior fontanelle delayed closure (AFDC) in infants and children under 3 years old,so as to provide evidence-based reference for diagnosis and treatment of delayed closure of AFDC. Methods Totally 61 infants with AFDC born from January 1st,2015 to December 31st,2015 and 183 infants with normal anterior fontanelle closure followed up for three years were enrolled in this study,variables such as birth weight,birth length,the size of anterior fontanelle at 1 month old,gender,mode of delivery,gestational age,fetus number,parity,the birth order,VA and VD average supplementation before two years old,the onset for adding complementary foods were compared between the two group. Results Univariate analysis showed that birth weight(χ²=8.309,P=0.016),the size of the anterior fontanelle at 1 month old (Z=-4.065,P＜0.001),VA average supplement before two years old (Z=-2.072,P=0.038) were associated with delayed anterior fontanelle closure in infants.Logistic regression showed the larger size of the anterior fontanelle at 1 month old (B=1.260,OR=3.526,P<0.001) was the main associated factors of delayed anterior fontanelle closure in infants,while perinatal and nutritional factors had no significant effect on the delayed closure of anterior fontanelle. Conclusions Delayed closure of anterior fontanelle is related to congenital enlargement of anterior fontanelle,and may be related to the nutritional status.But maternal perinatal status has no significant influence on the delayed closure of anterior fontanelle.

Key words: anterior fontanelle, delayed colsure, infants