孤独谱系障碍患儿消化道症状与行为表现关系分析

doi:10.11852/zgetbjzz2020-0412

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (11): 1259-1262.DOI: 10.11852/zgetbjzz2020-0412

孤独谱系障碍患儿消化道症状与行为表现关系分析

李玉勤¹, 孙映红¹, 梁亚鹏², 周凡¹, 杨洁¹, 金胜利¹, 梁爽³

1 江苏大学附属医院儿科,江苏镇江 212001;
2 江苏大学附属医院急诊科,江苏镇江 212001;
3 江苏省计划生育科学技术研究所,江苏南京 210036

收稿日期:2020-03-11 修回日期:2020-08-15 发布日期:2020-11-10 出版日期:2020-11-10
通讯作者: 梁爽,E-mail:289421301@qq.com
作者简介:李玉勤(1980-),女,河南人,副主任医师,硕士研究生,主要研究方向为小儿神经系统疾病的诊断和治疗。
基金资助:
江苏省人口学会开放基金资助项目(JSPA2019025)

Analysis on the relationship between gastrointestinal symptoms and behavioral manifestations in children with autism spectrum disorder

LI Yu-qin¹, SUN Ying-hong¹, LIANG Ya-peng², ZHOU Fan¹, YANG Jie¹, JIN Sheng-li¹, LIANG Shuang³

1 Department of Pediatrics,Jiangsu 212001,China;
2 Emergency Department,the Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu 212001,China;
3 Jiangsu Institute of Planned Parenthood Research, Nanjing, Jiangsu 210036, China

Received:2020-03-11 Revised:2020-08-15 Online:2020-11-10 Published:2020-11-10
Contact: LIANG Shuang,E-mail:289421301@qq.com

摘要/Abstract

摘要： 目的分析孤独谱系障碍(ASD)患儿消化道症状的检出率及消化道症状与行为表现之间的关系,为ASD的干预治疗提供新的思路。方法根据精神疾病诊断及统计手册第5版的诊断标准,选取2017年1月-2019年12月在江苏大学附属医院儿科儿童康复中心就诊的ASD患儿112例,选取正常儿童100例作为对照组。采用儿童孤独谱系障碍评定量表(CARS)、孤独谱系障碍儿童行为检查量表(ABC)对ASD患儿进行症状评估,采用Gesell发育量表(GDS)对ASD患儿进行发育评估,采用问卷调查儿童的消化道症状与行为表现。结果 ASD组消化道症状检出率显著高于对照组(72.3% vs.24.0%,χ²=33.012,P＜0.001)。将ASD患儿分为有消化道症状组(62例)和无消化道症状组(50例),两组间GDS、CARS和ABC评分比较差异无统计学意义(P>0.05);有消化道症状组情绪问题、行为问题(伤人/自伤)、重复刻板行为问题以及总评分明显高于无消化道症状组(t=4.868、4.101、4.812、5.968,P<0.001)。结论 ASD患儿消化道症状发生率明显高于正常儿童,有消化道症状比无消化道症状的ASD患儿具有更严重的情绪和行为问题,提示临床干预消化道症状可能对ASD患儿的康复有重要意义。

关键词: 孤独谱系障碍, 消化道症状, 行为表现, 儿童

Abstract: Objective To investigate the detection rate of gastrointestinal symptoms,and to analyze the association between gastrointestinal symptoms and behavioral manifestations in children with autism spectrum disorder(ASD),so as to provide new ideas for the intervention of ASD. Methods A total of 112 ASD children diagnosed according to the fifth edition of Diagnostic and Statistical Manual for Mental Disorders and 100 normal controls in the Department of Pediatrics of the Affiliated Hospital of Jiangsu University were enrolled in this study from January 2017 to December 2019.Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC) were used to assess the symptoms of autistic children,Gesell Development Scale (GDS) was used to evaluate the development of autistic children,and questionnaire was used to investigate the occurrence of gastrointestinal symptoms and behavior performance in children. Results The detection rate of gastrointestinal symptoms in ASD group was significantly higher than that in control group (72.3% vs.24.0%,χ²=33.012,P<0.001).ASD children were divided into the gastrointestinal symptoms group (n=62) and the gastrointestinal symptoms-free group (n=50).The differences of GDS,CARS and ABC between the two groups were not statistically significant (P>0.05).However,the score of emotional problems,behavioral problems,stereotypies or repetitive behaviors and the overall score in the gastrointestinal symptoms group were significantly higher than those in gastrointestinal symptoms-free group (t=4.868,4.101,4.812,5.968,P＜0.001). Conclusions The prevalence of gastrointestinal symptoms in ASD children is significantly higher than that in typical children.ASD children with gastrointestinal symptoms have more serious emotional and behavioral problems than children without gastrointestinal symptoms,indicating that clinical intervention of gastrointestinal symptoms may be of great significance to the rehabilitation of ASD children.

Key words: autism spectrum disorder, gastrointestinal symptoms, behavioral manifestations, children

中图分类号:

R725

李玉勤, 孙映红, 梁亚鹏, 周凡, 杨洁, 金胜利, 梁爽. 孤独谱系障碍患儿消化道症状与行为表现关系分析[J]. 中国儿童保健杂志, 2020, 28(11): 1259-1262.

LI Yu-qin, SUN Ying-hong, LIANG Ya-peng, ZHOU Fan, YANG Jie, JIN Sheng-li, LIANG Shuang. Analysis on the relationship between gastrointestinal symptoms and behavioral manifestations in children with autism spectrum disorder[J]. journal1, 2020, 28(11): 1259-1262.

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孤独谱系障碍患儿消化道症状与行为表现关系分析

Analysis on the relationship between gastrointestinal symptoms and behavioral manifestations in children with autism spectrum disorder

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