关键词: 1型黏蛋白, 白细胞介素-11, 新生儿, 坏死性小肠结肠炎

Abstract: Objective To investigate the changes and significance of type 1 mucin (MUC1) and interleukin-11 (IL-11) in the intestinal mucosa of neonatal necrotizing enterocolitis(NEC), so as to provide evidence for the prevention and treatment of NEC in clinical practice. Methods From February 2015 to July 2019, a total of 65 cases of intestinal mucosal tissue samples of postoperative NEC children in Children′s Hospital of Zhengzhou University were collected and selected as NEC group, and 30 cases of colonic specimens obtained from surgical treatment of congenital megacolon during the same period were selected as the control group.Specimens of two groups were detected by immunohistochemical staining.The positive expression rates of MUC1 and IL-11 protein were analyzed and compared between the two groups. Results Immunohistochemical staining analysis indicated that the positive expression rates of MUC1 and IL-11 protein in colonic mucosa of children in NEC group were 47.69% and 53.85%,respectively, which were 80.00% and 83.33% in control group, and the difference was significant(χ² =8.789, 7.670, P＜0.05).The positive expression rate of MUC1 and IL-11 protein in colonic mucosa were 33.33% and 40.00%, respectively, which were 60.00% and 65.71% in control group, and the difference was significant(χ² =4.605, 4.298, P＜0.05). Conclusions The expression of MUC1 and IL-11 protein in the intestinal mucosa of NEC children are significantly down-regulated, and the expression is more significantly down-regulated in the tissues with higher disease stages.Therefore, it is speculated that the decreased expression of these two proteins may be involved in the development of NEC.

Key words: Mucin type 1, interleukin-11, newborn, necrotizing enterocolitis