运动参与儿童早期发育表观遗传调控的认识进展

doi:10.11852/zgetbjzz2020-0876

摘要/Abstract

摘要： 在儿童早期发育过程中,表观遗传的动态编程一方面与婴幼儿时期的膳食平衡密切相关,同时也与儿童的身体运动紧密相连,它们共同影响了表观遗传修饰的上游代谢平衡,因此更完整地体现了儿童发育过程中遗传与体内环境的交互作用。为此,本文介绍了运动对机体表观遗传修饰的影响以及对下游功能基因的调控作用,重点强调了运动参与DNA甲基化、染色体组蛋白修饰和miRNA调控三个不同层面的表观遗传作用机制的文献进展。本文的介绍对儿童早期发育中的运动需求,尤其是儿童早期发育阶段的亲子运动提供了更为系统的表观遗传学依据。

关键词: 运动, 表观遗传学, 儿童早期发展

Abstract: During early childhood development,the dynamic programming of epigenetics is closely correlated with the dietary balance of infants and young children,but also closely related to children′s physical movement.Diet and physical movement jointly affect the upstream metabolic balance of epigenetic modification,which fully reflects the interaction between genetics and the internal environment during the development of children.To this end,this article introduces the effect of physical activities on the body′s epigenetic modification and even the regulation of downstream functional genes,with emphasis on the progress on epigenetics mechanism from three different levels:the participation of movement in DNA methylation,chromosomal histone modification and miRNA regulation,thereby providing a more systematic epigenetic basis for physical movement′s needs in early childhood development,especially for parent-child exercise in early childhood development.

Key words: physical activities, epigenetics, early childhood development

中图分类号:

R179

张霆. 运动参与儿童早期发育表观遗传调控的认识进展[J]. 中国儿童保健杂志, 2020, 28(6): 605-608.

ZHANG Ting. Progress on the understanding the involvement of exercise in epigenetic regulation of early childhood development[J]. journal1, 2020, 28(6): 605-608.

参考文献

[1] National Scientific Council on the Developing Child.Early experiences can alter gene expression and affect long-term development:Working paper No.10[R].National Scientific Council on the Developing Child,2010:12.
[2] Okano M,Bell DW,Haber D,et al.DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development[J].Cell,1999,99(3):247-257.
[3] Takizawa T,Nakashima K,Namihira M,et al.DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain[J].Dev Cell,2002,1(6):749-758.
[4] Ding Q,Vaynman S,Akhavan MM,et al.Insulin-like gro wth factor I interfaces with brain-derived neurotropic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function[J].Neuroscience,2006,140(3):823-833.
[5] Gomez-Pinilla F,Zhuang Y,Feng J,et al.Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation[J].Eur J Neurosci,2011,33(3):383-390.
[6] Sølvsten CA,de Paoli F,Christensen JH,et al.Voluntary ph ysical exercise induces expression and epigenetic remodeling of VegfA in the rat hippocampus[J].Mol Neurobiol,2016,55(1):567-582.
[7] Barrès R,Yan J,Egan B,et al.Acute exercise remodels promoter methylation in human skeletal muscle[J].Cell Metab,2012,15(3):405-411.
[8] Benevento M,van de Molengraft M,van Westen R,et al.The role of chromatin repressive marks in cognition and disease:A focus on the repressive complex GLP/G9a[J].Neurobiol Learn Mem,2015,124:88-96.
[9] Zhong T,Ren F,Huang CS,et al.Swimming exercise ameliorates neurocognitive impairment induced by neonatal exposure to isoflurane and enhances hippocampal histone acetylation in mice[J].Neuroscience,2016,316:378-388.
[10] de Meireles LC,Bertoldi K,Cechinel LR,et al.Treadmill exercise induces selective changes in hippocampal histone acetylation during the aging process in rats[J].Neurosci Lett,2016,634:19-24.
[11] Cechinel LR,Basso CG,Bertoldi K,et al.Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats[J].Behav Brain Res,2016,313:82-87.
[12] Spindler C,Cechinel LR,Basso C,et al.Treadmill exercise alters histone acetyltransferases and histone deacetylases activities in frontal cortices from wistar rats[J].Cell Mol Neurobiol.2014,34(8):1097-1101.
[13] 张霆,吴建新,李廷玉,等.儿童营养表观遗传学[M].北京:科学出版社,2019
[14] Zhang D,Tang Z,Huang H,et al.Metabolic regulation of gene expression by histone lactylation[J].Nature,2019,574(7779):575-580.
[15] Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281.
[16] Saab BJ,Mansuy IM.Neuroepigenetics of memory formation and impairment:The role of microRNAs[J].Neuropharmacology,2014,80:61-69.
[17] Mcneill E,van Vactor D.MicroRNAs shape the neuronal landscape[J].Neuron,2012,75(3):363-379.
[18] Lin Q,Wei W,Coelho CM,et al.The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory[J].Nat Neurosci,2011,14(9):1115-1117.
[19] Wayman GA,Davare M,Ando H,et al.An activity-regulated microrna controls dendritic plasticity by down-regulating P250gap[J].Proc Natl Acad Sci U S A,2008,105(26):9093-9098.
[20] Bao TH,Miao W,Han JH,et al.Spontaneous running wheel improves cognitive functions of mouse associated with miRNA expressional alteration in hippocampus following traumatic brain injury[J].J Mol Neurosci,2014,54(4):622-629.
[21] Valadi H,Ekström KK,Bossios A,et al.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
[22] Cortz MA,Bueso-Ramos C,Ferdin J,et al.MicroRNAs in body fluids--the mix of hormones and biomarkers[J].Nat Rev Clin Oncol,2011,8(8):467-477.
[23] Flowers E,Won GY,Fukuoka Y.MicroRNAs associated with exercise and diet:a systematic review[J].Physiol Genomics,2015,47(1):1-11.
[24] Radom-Aizik S,Zaldivar F,Szu-Yun Leu,et al.Effects of exercise on microRNA expression in young males peripheral blood mononuclear cells[J].Clin Transl Sci,2012,5(1):32-38.
[25] Joviic＇ A,Roshan R,Moisoi N,et al.Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of Neuronal Phenotypes[J].J Neurosci.,2013,33(12):5127-5137.
[26] Harraz MM,Eacker SM,Wang X,et al.MicroRNA-223 is neuroprotective by targeting glutamate receptors[J].Proceedings of the National Academy of Sciences,2012,109(46):18962-18967.
[27] Denham J,O′Brien BJ,Harvey JT,et al.Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans[J].Epigenomics,2015:1-15.
[28] Short AK,Yeshurun S,Powell R,et al.Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety[J].Transl Psychiatry.2017,7(5):e1114.
[29] Mcpherson NO,Owens JA,Fullston T,et al.Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring[J].Am J Physiol Endocrinol Metab,2015,308(9):E805-E821.
[30] Weissgerber TL,Wolfe LA,Davies GAL,et al.Exercise in the prevention and treatment of maternal-fetal disease:a review of the literature[J].Appl Physiol Nutr Metab,2006,31(6):661-74
[31] Clapp JF.Morphometric and neurodevelopmental outcome at age five years of the offspring of women who continued to exercise regularly throughout pregnancy[J].J Pediatr,1996,129(6):856-863.
[32] Esteban-Cornejo I,Martinez-Gomez D,Tejero-González,et al.Maternal physical activity before and during the prenatal period and the offspring′s academic performance in youth.The UP&DOWN study[J].J Matern Fetal Neonatal Med,2016,29(9):1414-1420.