关键词: 孤独症谱系障碍, 脑干听觉诱发电位, 儿童

Abstract: Objective To investigate the characteristics of brainstem auditory evoked potential (BAEP) in children with autism spectrum disorder (ASD) and normal hearing threshold in South China. Methods The BAEP records of ASD children in Guangzhou Women and Children's Medical Center between 2013 and 2018 were retrospectively reviewed. Healthy controls matched by age and gender were also recruited. The thresholds,wave absolute latencies (AL),wave inter peak intervals (IPL),Ⅰ-Ⅲ/Ⅲ-Ⅴ inter peak interval ratio and Ⅴ/Ⅰ amplitude ratio of BAEP between both groups were analyzed and compared. And the BAEP data of the children would be excluded from both groups if the hearing threshold of his/her ear exceeded 30 dB nHL. Results A total of 788 ASD children and 150 healthy controls were included. BAEP data of 1 530 ears in ASD group and 300 ears in control group were included in final analysis. All participants in the two groups could differentiate into well-defined waveforms of BAEP at 90 dB nHL sound stimulation. 1) The absolute latencies of wave Ⅰ,wave Ⅲ,wave V and inter peak intervals of Ⅰ-Ⅲ of ASD children were significantly longer than those of children in control group (Z=-2.006,-3.986,-2.552,-2.405,P<0.05).2) The abnormal ratio of Ⅰ-Ⅲ/Ⅲ-Ⅴ inter peak interval of ASD group (3.14%) was significantly higher than that of the control group(P<0.001). Conclusions There are distinct changes in BAEP in ASD children,especially the abnormal prolongation of brainstem conduction time,suggesting that ASD children may have brainstem dysfunction,which may lead to the damage of related information transmission.

Key words: autism spectrum disorder, brainstem auditory evoked potential, children