儿童MP-IgG与脂质代谢水平的相关性

doi:10.11852/zgetbjzz2022-0606

摘要/Abstract

摘要： 目的分析儿童肺炎支原体(MP)感染与高脂血症之间的关系,为儿童MP感染的防治提供更好的指导方案。方法收集蒲田学院附属儿科门诊2020年10月—2021年1月期间472名常规体检儿童的血清标本,对MP-IgG和脂质代谢指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)]分别进行检测。结果 MP-IgG阳性组TC、LDL-C水平均高于MP-IgG阴性组(Z=-2.746、-2.510,P<0.05)。MP-IgG阳性组的高TC血症比例大于MP-IgG阴性组(χ²=5.984,P=0.014)。MP-IgG等级与TC等级、LDL-C等级之间均存在统计学上的线性趋势(χ²=12.704、9.731,P<0.05),即剂量反应关系。Spearman相关性检验和Kendall'tau b 相关性检验均显示 MP-IgG与TC、LDL-C 呈正相关(P＜0.05)。多分类Logistic回归分析结果表明,高TC血症可能是影响儿童MP感染的重要因素,高TC血症儿童出现MP-IgG强阳性的概率是TC正常儿童的2.865倍(95%CI:1.202~6.832)。结论儿童MP感染与高脂血症存在相关性,适当降低TC水平可能有利于防治儿童MP感染。

关键词: 肺炎支原体, 感染, 脂质代谢, 高胆固醇血症, 儿童

Abstract: Objective To investigate the relationship between Mycoplasma pneumonia (MP) infection and hyperlipidemia in children, in order to provide better guidance for the prevention and treatment of MP infection in children. Methods Serum specimens were collected from 472 children who took routine physical examinations in pediatric outpatient clinic from October 2020 to January 2021.MP-IgG and lipid metabolism indicators, including triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), apolipoprotein Protein B (ApoB), was detected separately. Results The levels of TC and LDL-C in theMP-IgG positivegroup were higher than those in the MP-IgG negative group (Z=-2.746,-2.510, P＜0.05).The proportion of hypercholesterolemia in the MP-IgG positive group was significantly higher than that in theMP-IgG negative group (χ²=5.984, P=0.014).There was a statistically linear trend, also named a dose-response relationship, between MP-IgG grades and TC grades/LDL-C grades (χ²=12.704, 9.731, P＜0.05).Both Spearman correlation test and Kendall'tau b correlation test showed that MP-IgG was positively correlated with TC and LDL-C(P<0.05).Multi-class Logistic regression analysis showed that hypercholesterolemia may be an important factor affecting MP infection in children.The probability of MP-IgG positive in children with hypercholesterolemia was 2.865(95%CI:1.202 - 6.832) times that in children with normal TC. Conclusions There is a correlation between MP infection in children and hyperlipidemia.Appropriately reduction in cholesterol level may be beneficial to prevent and treat MP infection in children.

Key words: mycoplasma pneumoniae, infection, lipid metabolism, hypercholesterolemia, children

中图分类号:

颜桑桑, 张静霞, 徐美妹, 王桂芝, 朱棠, 韩丽红. 儿童MP-IgG与脂质代谢水平的相关性[J]. 中国儿童保健杂志, 2023, 31(8): 904-908.

YAN Sangsang, ZHANG Jingxia, XU Meimei, WANG Guizhi, ZHU Tang, HAN Lihong. Relationship between MP-IgG and lipid metabolism in children[J]. Chinese Journal of Child Health Care, 2023, 31(8): 904-908.

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