关键词: 低脂饮食, 认知, 强迫游泳实验, 高架十字迷宫

Abstract: 【Objective】 To observe the effects of low-fat diet on cognitive and emotional activities in juvenile rats. 【Method】 Low-fat diet was performed on SD rats, 14 days. continuously 4 weeks, Morris water maze, Elevated plus maze and Forced swim test were used to examined the capability of cognition, anxiety and depression. 【Results】 In low-fat diet group, the mean escape latency periods of four quadrants in Morris water maze test were (79.8±8.4) s, (80.1±7.7) s, (64.2±6.2) s, (59.8±6.0) s, respectively, which were longer obviously compared with the normal-fat diet rats (54.2±6.7) s, (55.6±5.8) s, (42.6±6.8) s, (41.7±5.8) s, (P<0.01); the rats with low-fat diet showed decreasing event on times crossing the target (1.7±0.5) than the normal-fat diet rats (3.2±0.8, P<0.01); In Force swim text, the latencies period of floating of low-fat diet rats(133.8±9.4) s, was shorter than that of normal-diet rats [(172.8±10.2) s,P<0.05)], and the duration of floating (418.2±13.8 s) was different apparently compared with the normal-diet rats(P<0.05) while normal-diet rats was (304.5±12.4)s. 【Conclusion】 Low-fat diet diminishes the capability of learning and memory of juvenile rats, and it may induce a certain depression symptom.

Key words: low-fat diet, cognition, force swim test, elevated plus maze