铁与儿童精神运动发育、认知功能和神经行为关系的研究进展

doi:10.11852/zgetbjzz2020-0541

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (8): 869-872.DOI: 10.11852/zgetbjzz2020-0541

铁与儿童精神运动发育、认知功能和神经行为关系的研究进展

赵春, 王成举综述, 胡斌审校

陆军军医大学第二附属医院儿科,重庆 400037

收稿日期:2020-03-26 修回日期:2020-09-14 发布日期:2021-08-25 出版日期:2021-08-10
通讯作者: 胡斌,E-mail:58127652@qq.com
作者简介:赵春(1987-),女,四川人,护师,主要研究方向为临床护理与儿童保健。
基金资助:
重庆市社会事业与民生保障科技创新专项(cstc2017shms130013)

Research progress on the association between iron and psychomotor development, cognitive function and neurobehavioral in children

ZHAO Chun, WANG Cheng-ju, HU Bin

Department of Pediatrics, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, China

Received:2020-03-26 Revised:2020-09-14 Online:2021-08-10 Published:2021-08-25
Contact: HU Bin, E-mail: 58127652@qq.com

摘要/Abstract

摘要： 铁是大脑新陈代谢的基本元素,缺铁可引起神经递质稳态的改变、减少髓鞘的产生、损害突触的形成、并使基底神经节功能下降,因此,缺铁性贫血会对精神运动发育、认知功能和神经行为产生不利影响,危害婴幼儿的健康发育。了解铁缺乏与精神运动发育、认知功能和神经行为的关系,弄清补充铁的疗效并在儿童保健时开展血清铁含量检验,对制定早期预防铁缺乏的公共卫生策略具有十分重要的意义。

关键词: 铁, 缺铁性贫血, 认知功能, 神经行为障碍, 儿童

Abstract: Iron is an essential element of brain metabolism. Iron deficiency can cause changes in the temperate of neurotransmitters, decrease myelin production, damage synapses, and decline the function of the basal ganglia. Therefore, iron deficiency anemia can adversely affect psychomotor development and cognitive function and endanger the healthy development of infants. Understanding the relationship between iron deficiency and psychomotor development, cognitive function and neurobehavioral, clarifying the efficacy of iron supplementation and carrying out the test of serum iron content in child care is of great significance in formulating public health strategies for early prevention of iron deficiency.

Key words: iron, iron deficiency anemia, cognitive function, neurobehavioral disorders, children

中图分类号:

R179

赵春, 王成举, 胡斌. 铁与儿童精神运动发育、认知功能和神经行为关系的研究进展[J]. 中国儿童保健杂志, 2021, 29(8): 869-872.

ZHAO Chun, WANG Cheng-ju, HU Bin. Research progress on the association between iron and psychomotor development, cognitive function and neurobehavioral in children[J]. Chinese Journal of Child Health Care, 2021, 29(8): 869-872.

参考文献

[1] Kassebaum NJ, GBD 2013 Anemia Collaborators. The global burden of anemia[J]. Hematol Oncol Clin North Am, 2016, 30(2): 247-308.
[2] Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010[J]. Blood, 2014, 123(5): 615-624.
[3] 杨晓光, 翟凤英, 朴建华, 等. 中国居民营养状况调查[J]. 中国预防医学杂志, 2010, 11(1): 5-7.
[4] 房红芸, 于冬梅, 郭齐雅, 等. 2013年中国0~5岁儿童贫血现状[J]. 中国公共卫生, 2018, 34(12): 1654-1657.
[5] Ferreira A, Neves P, Gozzelino R. Multilevel impacts of iron in the brain: the cross talk between neurophysiological mechanisms, cognition, and social behavior[J]. Pharmaceuticals (Basel), 2019, 12(3): E126.
[6] Vallée L. Iron and neurodevelopment[J]. Arch Pediatr, 2017, 24(Suppl 5):18-22.
[7] Sadeghzadeh M, Asl PK, Mahboubi E. Iron status and febrile seizure-a sase control study in children less than 3 years[J]. Iran J Child Neurol, 2012, 6(4):27-31.
[8] Kwak BO, Kim K, Kim SN, et al. Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta-analysis[J]. Seizure, 2017, 52: 27-34.
[9] Pala E,Erguven M, Guven S, et al. Psychomotor development in children with iron deficiency and iron-deficiency anemia[J]. Food Nutr Bull, 2010, 31(3): 431-435.
[10] Santos DCC, Angulo-Barroso RM, Li M, et al. Timing, duration, and severity of iron deficiency in early development and motor outcomes at 9 months[J]. Eur J Clin Nutr, 2018, 72(3): 332-341.
[11] Rothman M, Faber M,Covic N, et al. Infant development at the age of 6 months in relation to feeding practices, iron status, and growth in a peri-urban community of South Africa[J]. Nutrients, 2018, 10(1): E73.
[12] Wang B, Zhan S, Gong T, et al. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia[J]. Cochrane Detabase Syst Rev, 2013, 6(6): CD001444.
[13] Matiashvili K, Manjavidze N, Ghonghadze T. Influence of ferrotherapy on psychomotor development of children of yearly age with irondeficiency anemia[J]. Georgian Med News, 2012, 206: 38-41.
[14] 章逸莉, 郑双双, 朱柳燕, 等. 生命早期不同时期铁缺乏对儿童运动发育影响的纵向研究[J]. 中华儿科杂志, 2019, 57(3): 194-199.
[15] 傅晓燕. 婴幼儿铁缺乏症与脑发育障碍相关性研究[J]. 中国当代儿科杂志, 2018, 20(11): 964-967.
[16] Hurtado EK, Claussen AH, Scott KG. Early childhood anemia and mild or moderate mental retardation[J]. Am J Clin Nutr, 1999, 69(1): 115-119.
[17] Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years[J]. Arch Pediatr Adolesc Med, 2006, 160(11): 1108-1113.
[18] Baumgartner J, Smuts CM, Malan L,et al. Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone[J]. J Nutr, 2012, 142(8):1463-1471.
[19] Low M, Farrell A, Biggs BA,et al. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials[J]. CMAJ, 2012, 185(17): E791-E802.
[20] 朱柳燕, 邵洁. 铁缺乏与儿童执行功能的研究进展[J]. 中国儿童保健杂志, 2017, 25(4): 365-368.
[21] Kim J,Wessling-Resnick M. Iron and mechanisms of emotional behavior[J]. J Nutr Biochem, 2014, 25(11):1101-1107.
[22] Mahmoud MM, El-Mazary AA, Maher RM, et al. Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficithyperactivity disorder[J]. Ital J Pediatr, 2011, 37: 60.
[23] Bener A, Kamal M, Bener H, et al. Higher prevalence of iron deficiency as strong predictor attention deficit hyperactivity disorderin children[J]. Ann Med Health Sci Res, 2014, 4(Suppl 3): 291-297.
[24] Tseng PT, Cheng YS, Yen CF,et al. Peripheral iron levels in children with attention-deficit hyperactivity disorder: a systematic review and meta-analysis[J]. Sci Rep, 2018, 8(1): 788.
[25] Adisetiyo V, Helpern JA. Brain iron: a promising noninvasive biomarker of attention-deficit/hyperactivity disorder that warrants further investigation[J]. Biomark Med, 2015, 9(5): 403-406.
[26] 施卫萍,季加忠.营养性缺铁性贫血与注意缺陷多动障碍的临床关系研究258例病例分析[J]. 现代生物医学进展, 2007, 7(12): 1863-1865.
[27] Konofal E, Lecendreux M, Deron J, et al. Effects of Iron supplementation on attention deficit hyperactivity disorder in children[J]. Pediatr Neurol, 2008, 38(1): 20-26.
[28] Bener A, Khattab AO, Bhugra D, et al. Iron and vitamin D levels among autism spectrum disorders children[J]. Ann Afr Med, 2017, 16(4):186-191.
[29] Gunes S, Ekinci O, Celik T. Iron deficiency parameters in autism spectrum disorder: clinical correlates and associated factors[J]. Ital J Pediatr, 2017, 43(1): 86.
[30] Guo M, Li L, Zhang Q, et al. Vitamin and mineral status of children with autism spectrum disorder in Hainan Province of China: associations with symptoms[J]. Nutr Neurosci, 2018, 20: 1-8.
[31] 李圆圆,杨亭,刘娟,等.重庆市某特教机构3～7岁孤独症谱系障碍儿童营养情况调查[J].西安交通大学学报(医学版), 2019, 40(4): 629-634.
[32] Dosman CF, Brian JA, Drmic IE, et al. Children with autism: effect of iron supplementation on sleep and ferritin[J]. Pediatr Neurol, 2007, 36(3):152-158.
[33] Schmidt RJ,Tancredi DJ, Krakowiak P, et al. Maternal intake of supplemental iron and risk of autism spectrum disorder[J]. Am J Epidemiol, 2014, 180(9): 890-900.

铁与儿童精神运动发育、认知功能和神经行为关系的研究进展

Research progress on the association between iron and psychomotor development, cognitive function and neurobehavioral in children

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	向伟. 儿童青少年脂质异常血症早期预防与成人期心血管健康[J]. 中国儿童保健杂志, 2023, 31(7): 697-702.
[2]	吴婷, 李斐. 生命早期不利因素与慢性疾病的发生与预防[J]. 中国儿童保健杂志, 2023, 31(7): 703-706.
[3]	刘浩东, 李成, 赵敏, 席波. 儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 707-712.
[4]	刘敏, 张倩, 杨亭, 陈洁, 陈立, 代英, 贾飞勇, 武丽杰, 郝燕, 李玲, 张婕, 柯晓燕, 衣明纪, 洪琦, 陈津津, 方拴锋, 王益超, 王琦, 金春华, 李廷玉. 全国多中心学龄前儿童血清叶酸现况调查[J]. 中国儿童保健杂志, 2023, 31(7): 713-717.
[5]	霍言言, 刘钟泠, 马玲, 吴丹, 汪秀莲, 仇晓艳, 窦家莹, 任玉倩, 李亦诚, 洪霞, 陈津津. 真实世界2岁以下儿童不同体型匀称度现况及风险因素[J]. 中国儿童保健杂志, 2023, 31(7): 718-723.
[6]	刘慧娟, 宋志霄, 高南南, 张莉, 孙瑾, 乔秀芸, 柯佳媚, 李燕. 2～6岁儿童词汇和语法发展现状及相关因素分析[J]. 中国儿童保健杂志, 2023, 31(7): 724-730.
[7]	李荣, 李年, 吴丹丹, 黄荣, 陈银花. 盐酸哌甲酯缓释片对注意缺陷多动障碍儿童生长的影响[J]. 中国儿童保健杂志, 2023, 31(7): 731-735.
[8]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[9]	杨钰儒, 王红, 许树红, 曹艳梅, 孟仙, 葛冬梅. 0～14岁儿童骨骼发育与维生素K的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 746-750.
[10]	叶芝旭, 余福勋. 肠道微生物与儿童呼吸道病毒感染的研究进展[J]. 中国儿童保健杂志, 2023, 31(7): 766-769.
[11]	曹慧, 严双琴, 关宏岩. 亲子互动对儿童早期发展结局的影响[J]. 中国儿童保健杂志, 2023, 31(7): 770-774.
[12]	张容, 吴襄仪, 朱一民, 朱文丽, 《儿童肥胖预防与控制指南》修订委员会. 就餐地点与儿童肥胖的定性循证研究[J]. 中国儿童保健杂志, 2023, 31(7): 775-780.
[13]	李玮玮, 张丹丹, 刘晓鸣, 陈娇, 夏露. 探讨基于互联网技术的长程管理模式在难治性癫痫患儿中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 781-784.
[14]	朱丽君, 李彪章, 周嘉雯, 吴柏欣, 李卫东. 1990—2019年中国5岁以下儿童低体重疾病负担分析[J]. 中国儿童保健杂志, 2023, 31(7): 790-793.
[15]	曹亚船, 豆吉娟, 马亚萍, 任金冬, 陈新颜. 肥胖儿童脂质代谢与左心室肥厚及左心室重构的相关性[J]. 中国儿童保健杂志, 2023, 31(7): 809-812.