中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (11): 979-981.

• 科研论著 • 上一篇    下一篇

学龄前双生子儿童围度指标的遗传学研究

栾天抒,李玉玲,陆舜华,刘燕,郑玉娜,赵曼   

  1. 内蒙古师范大学生命科学与技术学院解剖生理学教研室,内蒙古 呼和浩特 010022
  • 收稿日期:2012-05-16 发布日期:2012-11-06 出版日期:2012-11-06
  • 通讯作者: 李玉玲,E-mail:liyuling137@163.com
  • 作者简介:栾天抒(1983-),女,内蒙古人,硕士在读,研究方向为人类遗传学
  • 基金资助:
    国家自然科学基金(30960167);国家自然科学基金(30371223);内蒙古自然科学基金(200508010507)

Genetics study on circumference in preschool-age twins

LUAN Tian-shu,LI Yu-ling,LU Shun-hua,LIU Yan,ZHENG Yu-na,ZHAO Man   

  1. Department of Anatomical Physiology,Institute of Life Science and Technology,Inner Mongolia Normal University,Huhhot,Inner Mongolia 010022,China
  • Received:2012-05-16 Online:2012-11-06 Published:2012-11-06

摘要: 【目的】 分析遗传和环境因素对学龄前双生子儿童围度发育的影响及其性别和年龄因素的作用。 【方法】 对3~6岁101对双生子(同卵双生子42对、同性别异卵双生子30对,异性别异卵双生子29对)的头围、胸围、腰围、臀围、上臂围及小腿围进行测量;对测量结果进行结构方程模型拟合,并估算各指标遗传度。 【结果】 最佳模型除头围为AES外,其他各指标均为ACES模型,遗传、环境、年龄因素对各指标均有不同程度影响。校正年龄后,各指标遗传度为:头围(男0.83,女0.75)、胸围(男0.56,女0.43)、腰围(男0.77,女0.72)、臀围(男0.49,女0.63)、上臂围(男0.58,女0.36)、小腿围(男0.82,女0.76)。 【结论】 学龄前儿童头围、腰围、小腿围主要受遗传因素影响,胸围、臀围、上臂围受环境因素影响相对较大。

关键词: 围度, 学龄前儿童, 双生子, 遗传度

Abstract: 【Objective】 To assess the genetic and environmental influences on body circumference of preschool-age children,and the effect of sex and age. 【Methods】 A total of 101 twin pairs aged 3~6 years old were measured,including 42 monozygotic (MZ),30 like-sex and 29 opposite-sex dizygotic (DZ).The circumference items included head circumference,chest circumference,waist circumference,hip circumference,arm circumference and calf circumference.The structural equation modeling was used to evaluate the heritability of each circumference item. 【Results】 Except head circumference's fitting model was AES,others were ACES,which indicated that the circumference items were influenced by genetic,environmental factors and age effects.After adjusting age,the heritabilities of head circumference,chest circumference,waist circumference,hip circumference,arm circumference and calf circumference were 0.83,0.56,0.77,0.49,0.58,0.82 in boys,and 0.75,0.43,0.72,0.63,0.36,0.76 in girls respectively. 【Conclusion】 The circumference of head,waist and calf of preschool-age children are mainly influenced by genetic factors,the circumferences of chest,hip and arm are mainly influenced on environmental ones.

Key words: circumference, preschool-age children, twins, heredity

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