关键词: 中性粒细胞明胶酶相关脂质运载蛋白, 铁代谢, 学龄前儿童, 贫血

Abstract: 【Objective】 To explore the correlation of neutrophil gelatinase-associated lipocalin (NGAL) and iron metabolic index,including hemoglobin (HB),serum ferritin (SF),serum transferrin receptor (sTfR),transferritin receptor-ferritin index (TFR-F) and body iron content (BIC). 【Methods】 About 473 preschool children with 2~7 years old were randomly selected from eight kindergartens,including 223 boys and 250 girls with (47.8±14.5) months.HB was measured by HiCN method,NGAL,SF and sTfR by ELISA.TFR-F index and BIC were calculated according to the relevant index formula. 【Result】 There were significant correlation between NGAL and sTfR,TFR-F and BIC (the partial correlation coefficients were 0.23,0.24 and -0.15,P<0.01 or <0.05),respectively.The value of serum NGAL in anemic children was markedly higher than that of non-anemic children [(152.8±33.4) vs (220.7±25.4)pg/mL](P<0.05).Children with low sTfR level (cut by sTfR media value) had lower serum NGAL level than those with high sTfR level[(181.05±41.1) vs (257.6±47.8)pg/mL](P<0.05);however,children with low BIC level (cut by BIC media value) had higher serum NGAL level than those with high BIC level [(269.1±49.4) vs (181.3±30.8)pg/mL](P<0.05).The values of sTfR and TFR-F in children with low NGAL level (cut by NGAL media level) were significantly lower than those of children with high NGAL level (P<0.05),but not for HB,SF and BIC (P>0.05). 【Conclusion】 The impact of NGAL on iron metabolism may be mainly through the inhibition on erythroid proliferation,but no relationship with iron reserves process.

Key words: neutrophil gelatinase-associated lipocalin, iron metabolism, preschool children, anemia