关键词: 先天性甲状腺功能减低症, 骨密度, 儿童

Abstract: 【Objective】 To observe the bone mineral density (BMD) in children with congential hypothyroidism (CH) detected by neonatal screening program and analyze the effects of the disease itself or therapy factors on BMD. 【Method】 BMD was measured in 30 young children (1~2 years old) with CH and 68 normal children controls. 【Results】 There was no significant difference between the patients and controls for BMD.The BMD of the CH patients had significant correlation with the severity of thyroid gland hypoplasia and FT₄ level at the time of CH were diagnosed. 【Conclusions】 The BMD of the children with CH are with the normal range.The severity of thyroid gland hypoplasia and FT₄ level at the time of CH diagnosed have significant effects on BMD.

Key words: congential hypothyroidism, bone mineral density, children