不同品系大鼠开场自发活动水平的研究

中国儿童保健杂志 ›› 2013, Vol. 21 ›› Issue (12): 1277-1278.

不同品系大鼠开场自发活动水平的研究

徐冬,田苑,马欣欣,李辉,王亚萍

西安交通大学第二附属医院,陕西西安 710004

收稿日期:2013-09-23 发布日期:2013-12-06 出版日期:2013-12-06
通讯作者: 王亚萍,E-mail:wyp63@hotmail.com
作者简介:徐冬(1988-),男,硕士研究生在读,研究方向为儿童精神病学。
基金资助:
陕西省科技攻关项目(2012SF2-10)

Study of spontaneous activity level in rats of different breeds.

XU Dong,TIAN Yuan,MA Xin-xin,LI Hui,WANG Ya-ping.

The Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China

Received:2013-09-23 Online:2013-12-06 Published:2013-12-06
Contact: WANG Ya-ping,E-mail:wyp63@hotmail.com

摘要/Abstract

摘要： 目的以常用的注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)模型自发性高血压大鼠(spontaneously hypertensive rats,SHR)为观察对象,观察其与注意缺陷多动障碍临床特征在行为学上的相似性。方法 SHR、SD(Sprague Dawley rats,SD)、WKY(Wistar Kyoto rats,WKY)大鼠各10只,利用开场实验观察记录大鼠穿越的格子数、直立次数、理毛次数、粪便颗粒数。结果反映大鼠活动能力的穿越格数及直立次数,SHR大鼠均明显较对照组WKY、SD大鼠增多,差异有高度统计学意义(P<0.01);而表现情绪紧张程度的理毛次数和排便粒数,SHR大鼠与对照组WKY、SD大鼠的差异无统计学意义(P>0.05)。结论 SHR大鼠的多动性明显高于SD、WKY大鼠,能很好的再现注意缺陷多动障碍的多动行为学特征,是比较理想的注意缺陷多动障碍的动物模型。

关键词: 注意缺陷多动障碍, 自发性高血压大鼠, WKY, SD, 开场实验

Abstract: Objective To observe the behavioral characteristics of animal models of spontaneously hypertensive rats (SHR) with attention deficit hyperactivity disorder (ADHD)on the behavior of the similarity. Methods 10 spontaneously hypertensive rats (SHR),Sprague Dawley rats (SD),Wistar Kyoto rats (WKY) rats in each.The panels the rats passed,the times of straighten and grooming,and times of dejecture were observed and recorded by using open-field environment test. Results The panels passed and the times of straightening SHR rats were significantly higher than those of the SD and WKY rats(P<0.01);the times of grooming and dejecture of SHR rats had no differences with the other groups(P>0.05). Conclusions SHR rats with significantly higher hyperactivity than SD WKY rats,could be a very good representation of hyperactivity behavior of characteristics,and be ideal animal models of ADHD.

Key words: attention deficit hyperactivity disorder, spontaneously hypertensive rats, Wistar Kyoto rats, Sprague Dawley rats, the open field test

中图分类号:

R749.94

徐冬,田苑,马欣欣,李辉,王亚萍. 不同品系大鼠开场自发活动水平的研究[J]. 中国儿童保健杂志, 2013, 21(12): 1277-1278.

XU Dong,TIAN Yuan,MA Xin-xin,LI Hui,WANG Ya-ping.. Study of spontaneous activity level in rats of different breeds.[J]. journal1, 2013, 21(12): 1277-1278.

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