尿液双酚A浓度及生活习惯与女童性早熟关系的研究

中国儿童保健杂志 ›› 2013, Vol. 21 ›› Issue (3): 237-240.

尿液双酚A浓度及生活习惯与女童性早熟关系的研究

陈瑶,黄红,沈理笑,吕莹波

上海交通大学医学院附属新华医院儿童与青少年保健科,环境与儿童健康教育部和上海市重点实验室,上海 200092

收稿日期:2012-06-11 发布日期:2013-03-06 出版日期:2013-03-06
通讯作者: 黄红,E-mail:huanghong@smhb.gov.cn;沈理笑,E-mail:kcb096@163.com
作者简介:陈瑶(1987-),女,江西人,在读硕士,研究方向为青少年健康教育。
基金资助:
上海交通大学医学院基金(YZ1065)

Urine bisphenol-A level and habits of life in relation to precocious puberty in girls.

CHEN Yao,HUANG Hong,SHEN Li-xiao,LV Ying-bo.

Department of Child and Adolescent Healthcare,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,MOE-Shanghai Key Laboratory of Children's Environmental Health,Shanghai 200092,China

Received:2012-06-11 Online:2013-03-06 Published:2013-03-06

摘要/Abstract

摘要： 目的探讨双酚A与女童性早熟发病的关系;首次尝试了解生活习惯与双酚A暴露及性早熟的关系。方法收集2011年7-12月于本院门诊就诊的性早熟病例组和正常对照组女童各44例;采用高效液相色谱法分别检测两组女童尿液双酚A浓度;通过自编问卷了解日常生活中可能存在双酚A暴露的生活习惯。结果病例组和对照组尿液双酚A检出率分别为70.45%和43.18%,差异有统计学意义(χ²=6.67,P<0.05);病例组尿液双酚A浓度高于对照组(Z=3.49,P<0.01);是否饮用桶装水热水可能是女童患有性早熟的弱危险因素(β=0.967 8,χ²=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004~6.903)。结论双酚A暴露可能与女童性早熟发病有关;正常对照组女童亦有较高的双酚A暴露率;尿样更适合用来评估人体双酚A暴露情况;常饮用桶装水热水可能增加女童患性早熟的风险;正确合理地使用塑料制品十分重要。

关键词: 病例对照研究, 性早熟, 双酚A, 生活习惯

Abstract: Objective To investigate the relationship between bisphenol-A(BPA) and precocious puberty in girls and study the relationship between life style and BPA exposure and precocious puberty first time. Methods 44 precocious girls as the case group and 44 normal girls as the control group were recruited from July to December in 2011.The concentrations of BPA in urine samples were measured by using high performance liquid chromatography (HPLC).The data of life style was learned through self made-up questionnaire. Results The positive rate of BPA in the case group (70.45%) was significantly higher than the control group (43.18%) (χ²=6.67,P<0.05).The concentrations of BPA in urine samples from the case group were significantly higher than samples from the control group,too (Z=3.49,P<0.01).The habit of hot water drinking from barreled water might be a week risk factor of precocious puberty in girls (β=0.967 8,χ²=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004~6.903). Conclusions The exposure of BPA may be associated with the onset of precocious puberty in girls.The positive rate of BPA in the control group is high.Urine is considered to be the appropriate sample for BPA detection.The habit of hot water drinking from barreled water may slightly increase the risk of precocious puberty in girls.It's absolutely important to learn how to use plastics in the right way.

Key words: case-control study, precocious puberty, bisphenol-A, life style

中图分类号:

R725.8

陈瑶,黄红,沈理笑,吕莹波. 尿液双酚A浓度及生活习惯与女童性早熟关系的研究[J]. 中国儿童保健杂志, 2013, 21(3): 237-240.

CHEN Yao,HUANG Hong,SHEN Li-xiao,LV Ying-bo.. Urine bisphenol-A level and habits of life in relation to precocious puberty in girls.[J]. journal1, 2013, 21(3): 237-240.

参考文献

[1] 申甜,李缤.环境内分泌干扰物与儿童性指标的关系[J].中国临床康复,2006,10(28):135-137.
[2] 宁寿葆.现代实用儿科学[M].上海:复旦大学出版社,2004:820-825.
[3] He Y,Miao M,Herrinton LJ,et al.Bisphenol A levels in bood and urine in a Chinese population and the personal factors affecting the levels[J].Environ Res,2009,109(5):629-633.
[4] Calafat AM,Ye X,Wong LY,et al.Exposure of the U.S.population to bisphenol A and 4-tertiary-octylphenol:2003-2004[J].Environ Health Perspect,2008,116(1):39-44.
[5] Calafat AM,Kuklenyik Z,Reidy JA,et al.Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population[J].Environ Health Perspect,2005,113(4):391-395.
[6] Li DK,Zhou Z,Miao M,et al.Urinary bisphenol-A(BPA) level in relation to semen quality[J].Fertil Steril,2011,95(2):625-630.
[7] Sohoni P,Sumpter JP.Several environmental oestrogens are also anti- androgens[J].Journal of Endocrinology,1998,158(3):327-339.
[8] Honma S,Suzuki A,Buchanan DL,et al.Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction[J].Reprod Toxicol,2002,16(2):117-122.
[9] 乔丽丽,郑力行,蔡德培.性早熟女童血清双酚A、辛基酚、4-壬基酚测定和分析[J].卫生研究,2010,39(1):9-12.
[10] 陈瑶,黄红,沈理笑.双酚A人体内外暴露现状及对健康的影响[J].环境与职业医学,2011,28(12):769-773.
[11] Ferrer E,Santoni E,Vittori S,et al.Simultaneous determination of bisphenol A,octylphenol,and nonylphenol by pressurised liquid extraction and liquid chromatography-tandem mass spectrometry in powdered milk and infant formulas[J].Food Chemistry,2011,126(1):360-367.
[12] Cunha SC,Almeida C,Mendes E,et al.Simultaneous determination of bisphenol A and bisphenol B in beverages and powdered infant formula by dispersive liquid-liquid micro-extraction and heart-cutting multidimensional gas chromatography-mass spectrometry[J].Food Additives and Contaminants,2011,28(4):513-526.
[13] Li X,Ying GG,Su HC,et al.Simultaneous determination and assessment of 4-nonylphenol,bisphenol A and triclosan in tap water,bottled water and baby bottles[J].Environment International,2010,36(6):557-562.

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