儿童孤独症发病危险因素的病例对照研究

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (1): 24-27.

儿童孤独症发病危险因素的病例对照研究

冼丹霞¹, 金宇¹, 谢笑英², 林美英³, 张玲¹, 黎超娟^{1, 4}, 红荣^{1, 5}

1 中山大学公共卫生学院, 广东广州 510080;
2 黄埔区妇幼保健院, 广东广州 510070;
3 黄埔区鱼珠街社区卫生服务中心, 广东广州 510070;
4 台山市妇幼保健院, 广东台山 529200;
5 内蒙古医科大学, 内蒙古呼和浩特 010050

收稿日期:2013-08-30 发布日期:2014-01-10 出版日期:2014-01-10
通讯作者: 金宇, E-mail:jinyu@mail.sysu.edu.cn
作者简介:冼丹霞(1987-), 女, 广东人, 在读研究生, 学士学位, 主要研究方向为临床儿童心理诊疗。
基金资助:
国家自然基金项目(81171293);广东省科技计划项目(2011B031800020);广州市科信局科普项目(2012KP049)

Case-control study on risk factors of childhood autism.

XIAN Dan-xia¹, JIN Yu¹, XIE Xiao-ying², LIN Mei-ying³, ZHANG Ling¹, LI Chao-juan^{1, 4}, HONG Rong^{1, 5}.

1 Public Health School of SUN Yat-sen University, Guangzhou, Guangdong 510080, China; 2 Maternal and Child Health Hospital of Huangpu District, Guangzhou, Guangdong 510070, China; 3 Yuzhu Street Community Health Center of Huangpu District, Guangzhou, Guangdong 510070, China; 4 Maternal and Child Health Hospital of Taishan, Taishan, Guangdong 529200, China; 5 Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China

Received:2013-08-30 Online:2014-01-10 Published:2014-01-10
Contact: JIN Yu, E-mail:jinyu@mail.sysu.edu.cn

摘要/Abstract

摘要： 目的探讨儿童孤独症发病的相关危险因素, 为孤独症的防治提供理论依据。方法采用成组病例对照研究, 对165例孤独症儿童和320例正常对照组儿童, 采用自编的孤独症危险因素调查表收集相关危险因素、家庭一般情况等资料, 用χ²检验分析两组儿童之间危险因素的差异。结果病例组母亲高生育年龄(≥35岁)、有人工流产史、母孕期抑郁情绪史、母孕期被动吸烟史及父亲内向所占比例较正常组高(P<0.05), 进一步进行Logistic 回归分析显示母高育龄、孕期抑郁情绪、孕期被动吸烟、有人工流产史以及父亲性格内向为孤独症的危险因素。结论母亲高龄生育、有人工流产史、孕期抑郁情绪、孕期被动吸烟以及父亲性格内向均可使儿童孤独症发病风险增高。

关键词: 孤独症, 危险因素, 儿童

Abstract: Objective To find out risk factors associated with children with autism and to offer the basis for autistic prevention work. Methods There were 165 patients children with autism and 320 patientscontrol group of children in the case-control study.Questionnaires were used to make up by ourselves to collect maternal risk factors, family and other general information, and then used Chi-square test to analyze the two sets of children's differences in risk factors. Results The proportion of higher maternal age (≥35 years old) and father introverted, higher maternal induced abortion, maternal depression and passive smoking during the pregnant time in autism group were higher than those in the normal group (P<0.05), and logistic analysis showed that higher maternal age, father introverted, higher maternal induced abortion, maternal depression and passive smoking during the pregnant time were the risk factors to autism in children. Conclusion Mother aged (≥35 years old), a history of induced abortion, passive smoking and depression in gestation period and father introverted are risk factors to autism.

Key words: autism, risk factors, children

中图分类号:

R749.94

冼丹霞, 金宇, 谢笑英, 林美英, 张玲, 黎超娟, 红荣. 儿童孤独症发病危险因素的病例对照研究[J]. 中国儿童保健杂志, 2014, 22(1): 24-27.

XIAN Dan-xia, JIN Yu, XIE Xiao-ying, LIN Mei-ying, ZHANG Ling, LI Chao-juan, HONG Rong.. Case-control study on risk factors of childhood autism.[J]. journal1, 2014, 22(1): 24-27.

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