关键词: 孤独症, 脑影像学, 儿童, 资料分析

Abstract: Objective To explore the characteristics of brain imaging in autism. Methods Structural and functional brain imaging of 368 children with autism were analyzed retrospectively. Results The abnormality rate of MRI(35.5%,55/155) was higher than that of CT(12.7%,26/205),the main abnormal positions were the cerebral cortex,white matter,cerebellum,basal ganglia and the ventricular system in autistic brain.There were SPECT,fMRI,MRS,DTI for functional brain imaging,SPECT was the more commonly used.31 cases of SPECT showed that the cerebral blood flow perfusion was changed locally in all children,the regional cerebral blood flow was reduced in 26 cases,the incidence rate was 83.9%,mainly in the frontal lobe,temporal lobe,parietal lobe and hippocampus.The parts of regional cerebral blood flow perfusion increased were all in the basal ganglia region. Conclusions The occurrence of autism is closely related to the changes of structure or function of multiple part of brain.Functional brain imaging is more sensitive than structural imaging on autism pathogenesis studies,which is considered worthy of application and further study.

Key words: autism, brain imaging, children, data analysis