关键词: 氨基酸, 静脉营养, 生长发育, 早产儿

Abstract: Objective To assess the effectiveness of early different doses of intravenous amino acid supplementation in preterm infants. Methods According different intravenous amino acid administration,one hundred and forty-six preterm infants (fetal age 29~34,birth weight 1 150~2 250 g) were randomly divided into low dose,median dose,high dose groups.The infants in high dose group were treated with amino acid 2.0 g/(kg·d) within 24 hours,increasing by 1.0 g per day;The median dose group was treated with amino acid 1.0g/(kg·d),increasing by 0.5 g per day;The low dose group was treated with amino acid 0.5 g/(kg·d),increasing by 0.5 g per day. Results The time of rebounding to birth weigh in the high dose group was less than that in the median and low dose group;In two weeks after birth,the rate of weight again in the high dose group was highest than that in other dose groups;In the high dose group,time of achieving enteral nutrition of 100 kCal/kg days was lower than that in other dose groups (P<0.05).On the fourteenth day after birth,there was no significant difference in urea nitrogen,creatinine,PH value,base excess,serum bilirubin and total bile acid among the three groups (P>0.05). Conclusion Early higher doses of amino acid supplementation is beneficial to preterm infants' early growth and nutrition with little incidence of metabolic acidosis,renal dysfunction or cholestasis.

Key words: amino acid, intravenous nutrition, growth and development, preterm infant