关键词: 早产极低出生体重儿, 早期生长, 肠外营养, 肠内营养

Abstract: Objective To investigate the relationship between early growth of preterm very low birth weight infant (VLBWI) and parenteral and enteral nutrition,so as to provide scientific basis for parenteral nutrition (PN) and enteral nutrition (EN) regimen in clinical practice. Methods All eligible VLBWIs were divided into two groups according to the change of Z-score (ΔWt SDS) between birth and correct gestational age at discharge for body weight:non-catch-down (NCD) group,ΔWt SDS≥-0.67;catch-down (CD) group:ΔWt SDS＜-0.67.Clinical data were analyzed between the two groups. Results There were 92 cases in NCD group and 85 cases in CD group.No significant differences were found in incidence of maternal complications,birth anthropometric parameters (weight,length,head circumference) and relative anthropometric parameters Z-score between the two groups (P＞0.05).The NCD group had better anthropometric parameters and relative anthropometric parameters Z-score than the CD group at discharge (P＜0.05 or ＜0.01).The NCD group had lower incidence of bronchopulmonary dysplasia and parenteral nutrition associated cholestasis than the CD group (P＜0.05).The NCD group had significant lower PN duration than the CD group (P＜0.01).The NCD group had higher PN energy intake than the CD group from day 5 to day 7 (P＜0.05).However,the NCD group had lower PN energy intake than the CD group from week 2 to week 6 (P＜0.05).The NCD group had higher EN feeding volume from day 5 to week 6 (P＜0.05 or ＜0.01).The NCD group had higher EN and PN total protein intake from day 5 to week 5 (P＜0.05). Conclusion Adequate PN lipid and energy intake during the first week of life,enhanced EN feeding volume could shorten PN duration and improve early growth of VLBWI.

Key words: preterm very low birth weight infant, early growth, parenteral nutrition, enteral nutrition