脐血25-羟基维生素D水平与6月龄婴儿特应性皮炎的发生及严重程度的关系

doi:10.11852/zgetbjzz2019-0497

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (10): 1115-1119.DOI: 10.11852/zgetbjzz2019-0497

脐血25-羟基维生素D水平与6月龄婴儿特应性皮炎的发生及严重程度的关系

王静¹, 张悦², 谭美珍¹, 肖玉联¹, 韦茹¹, 汪玲华³

1 广州市妇女儿童医疗中心保健科,广东广州 510120;
2 广州市妇女儿童医疗中心儿科研究所,广东广州 510623;
3 广州市妇女儿童医疗中心心理科,广东广州 510120

收稿日期:2019-04-10 发布日期:2019-10-10 出版日期:2019-10-10
通讯作者: 汪玲华,E-mail:13710573018@163.com
作者简介:王静(1982-),女,四川人,主治医师,硕士学位,研究方向为早期营养对婴幼儿生长发育的影响。
基金资助:
广州市卫生和计划生育科技项目(20181A011029);广州市妇女儿童医疗中心儿科研究所内部基金(YIP-2016-002);广东省医学科学技术研究基金项目(A2018239)

Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants

WANG Jing¹, ZHANG Yue², TAN Mei-zhen¹, XIAO Yu-lian¹, WEI Ru¹, WANG Ling-hua³

1 Department of Child Healthcare,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510120,China;
2 Institute of Pediatrics,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510623,China;
3 Department of Psychological,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510120,China

Received:2019-04-10 Online:2019-10-10 Published:2019-10-10
Contact: WANG Ling-hua,E-mail:13710573018@163.com

摘要/Abstract

摘要： 目的分析新生儿脐血25-羟基维生素D[25-(OH)D]水平与婴儿特应性皮炎(AD)的关系,为婴儿AD的一级预防及早期干预提供依据。方法 2016年12月-2017年12月前瞻性连续选取孕期妇女及其所生婴儿202对,出生时留取脐血,跟踪至婴儿6月龄,采用标准问卷调查获取父母及婴儿资料,酶联免疫吸附试验检测脐血血清25-(OH)D水平。通过客观的SCORAD评分评估AD患儿病情的严重程度。用巢式病例对照及Logistic回归的方法分析影响婴儿AD发生的危险因素。结果脐血25-(OH)D水平在AD患儿及健康对照组中的差异无统计学意义,家族过敏史阳性(OR=1.963)、非纯母乳喂养(OR=2.089)、夏季出生(OR=2.265)是影响AD发生的危险因素(P<0.05)。脐血25-(OH)D水平与婴儿AD的严重程度负相关(r =-0.325,P=0.023)。结论脐血25-(OH)D不是预测婴儿AD发生的危险因素,但与AD发生的严重程度负相关,孕期合理地补充维生素D可能会减轻婴儿AD的严重程度。

关键词: 脐血, 25-羟基维生素D, 特应性皮炎, 婴儿

Abstract: Objective To analyze the relationship between cord blood 25-hydroxyvitamin D [25-(OH)D] and infant atopic dermatitis(AD),in order to provide reference for the primary prevention and early intervention for AD in infants. Methods Totally 202 mothers and their infants were enrolled in this study from December 2016 to December 2017.Cord blood was collected at birth,and the children were followed up to 6 months old.A standard questionnaire was used to obtain the information of parents and infants,serum level of cord blood 25-(OH)D was detected by enzyme-linked immunosorbent assay.Objective Scoring of Atopic Dermatitis(SCORAD) was used to assess the severity of AD in infants.And the risk factors for AD in infants were analyzed by nested case-control study and Logistic regression analyzed. Results There was no statistically significant difference on cord blood level of 25-(OH)D between AD group and the healthy control group .Positive family history of allergy (OR=1.963),non-exclusive breastfeeding (OR=2.089),and birth in summer (OR=2.265) were risk factors for the occurrence of AD(P＜0.05).Cord blood levels of 25-(OH)D was negatively correlated with the severity of AD in infants (r=-0.325,P=0.023). Conclusions Cord blood 25-(OH)D can not predict the occurrence of AD in infants,but it is negatively correlated with the severity of AD.Reasonable vitamin D supplementation during pregnancy may reduce the severity of AD in infants.

Key words: cord blood, 25-hydroxyvitamin D, atopic dermatitis, infant

中图分类号:

R179

王静, 张悦, 谭美珍, 肖玉联, 韦茹, 汪玲华. 脐血25-羟基维生素D水平与6月龄婴儿特应性皮炎的发生及严重程度的关系[J]. 中国儿童保健杂志, 2019, 27(10): 1115-1119.

WANG Jing, ZHANG Yue, TAN Mei-zhen, XIAO Yu-lian, WEI Ru, WANG Ling-hua. Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants[J]. journal1, 2019, 27(10): 1115-1119.

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脐血25-羟基维生素D水平与6月龄婴儿特应性皮炎的发生及严重程度的关系

Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants

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