支原体肺炎患儿的血清淀粉样蛋白A及人软骨糖蛋白-39水平变化与及预后的相关性分析

doi:10.11852/zgetbjzz2018-1049

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (3): 314-316.DOI: 10.11852/zgetbjzz2018-1049

支原体肺炎患儿的血清淀粉样蛋白A及人软骨糖蛋白-39水平变化与及预后的相关性分析

张慧,陈皓

十堰市妇幼保健院儿科,湖北十堰 442000

收稿日期:2018-08-02 修回日期:2018-10-11 发布日期:2019-03-20 出版日期:2019-03-20
通讯作者: 陈皓,E-mail:hhsj023@163.com
作者简介:张慧(1983-),女,主治医师,本科学历,主要研究方向为儿科。

Analysis of serum amyloid A and human cartilage glycoprotein-39 levels in children with mycoplasmal pneumonia and the correlation with prognosis

ZHANG Hui,CHEN Hao

Shiyan Maternaland Child Health Hospital,Shiyan,Hubei 442000,China

Received:2018-08-02 Revised:2018-10-11 Online:2019-03-20 Published:2019-03-20
Contact: CHEN Hao,E-mail:hhsj023@163.com

摘要/Abstract

摘要： 目的分析支原体肺炎(MP)小儿的血清淀粉样蛋白A(SAA)及人软骨糖蛋白-39(HC-gp39)水平及与病情的相关性,为科学预测MP患儿预后提供依据。方法选取本院2015年2月-2017年2月收诊的110例支原体肺炎患儿纳入观察组,110例健康体检儿童纳入对照组。观察组患儿均予常规综合治疗。比较两组入院时及观察组治疗前后血清SSA、HC-gp39、IgA、IgG、IgM水平。观察组患儿根据治疗效果分为有效组与无效组,分析治疗前血清SSA及HC-gp39水平与预后的相关性。结果观察组入院时的血清SSA、HC-gp39、IgG水平显著高于同期对照组(t=32.204,20.597,11.588,P＜0.05)。观察组治疗后的血清SSA、HC-gp39、IgG水平较治疗前显著降低(t=27.859,13.765,35.043,P＜0.05)。血清SSA、HC-gp39与IgG呈正相关(r=0.524,0.394,P＜0.05),与疗效呈负相关(r=-0.613,-0.502,P＜0.05)。结论支原体肺炎患儿的血清SSA与HC-gp39水平明显高于健康儿童,且与IgG呈正相关,与病情严重比呈负相关。

关键词: 支原体肺炎, 血清淀粉样蛋白A, 人软骨糖蛋白-39, 预后

Abstract: Objective To analyze levels of serum amyloid A(SAA)and human cartilage glycoprotein-39(HC-gp39) in children with mycoplasma pneumonia(MP),as well as the correlation with efficacy,in order to provide reference for predicting the prognosis of MP children. Methods Totally 110 MP children in Shiyan Maternal and Child Health Hospital were enrolled in the observation group and 110 healthy children were included in the control group from February 2015 to February 2017. The observation group was given conventional comprehensive treatment. The levels of serum SAA,HC-gp39,IgA,IgG and IgM of two groups at admission,before and after treatment in observation group were compared. After treatment,the observation group was divided into effective group and invalid group according to the treatment efficacy results. Pearson correlation analysis was used to determine the correlation between serum SSA and HC-gp39 levels before treatment and the efficacy. Results The serum SSA,HC-gp39,and IgG levels at admission in the observation group were significantly higher than those in control group(P<0.05). After treatment,the serum levels of SSA,HC-gp39,and IgG in observation group were lower than those before treatment(P<0.05). The serum SSA,HC-gp39 levels were positively correlated with IgG(r=0.524,0.394,P<0.05) and negatively related to efficacy(r=-0.613,-0.502,P<0.05). Conclusion The levels of serum SSA and HC-gp39 in MP children are significantly higher than those in healthy children,and are positively correlated with IgG and negatively correlated with efficacy.

Key words: mycoplasma pneumonia, serum amyloid A, human chondro-glycoprotein-39, prognosis

中图分类号:

R722

张慧,陈皓. 支原体肺炎患儿的血清淀粉样蛋白A及人软骨糖蛋白-39水平变化与及预后的相关性分析[J]. 中国儿童保健杂志, 2019, 27(3): 314-316.

ZHANG Hui,CHEN Hao. Analysis of serum amyloid A and human cartilage glycoprotein-39 levels in children with mycoplasmal pneumonia and the correlation with prognosis[J]. journal1, 2019, 27(3): 314-316.

参考文献

[1] 盛小军,赵子文,赵祝香,等.血清淀粉样蛋白A、干扰素-G诱导蛋白10及降钙素原在AECOPD中的诊断意义[J].实用医学杂志,2016,32(8):1277-1279.
[2] 王幕逖.儿科学[M].5版.北京:人民卫生出版社,2005:21-22.
[3] 田沁,杨岚.鼻塞式持续性气道正压通气治疗小儿重症肺炎的临床效果[J].实用心脑肺血管病杂志,2016,24(6):115-117.
[4] Christensen MB,Langhorn R,Goddard A,et al. Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs[J].Can Vet J,2014,55(2):161-168.
[5] Azurmendi L,Degos V,Tiberti N,et al. Measuring serum amyloid A for infection prediction in aneurysmal subarachnoid hemorrhage[J].J Proteome Res,2015,14(9):3948-3956.
[6] 尹燕丹,阮荣华.肺炎支原体肺炎患儿混合感染的临床特征及影响因素的分析[J].浙江临床医学,2016,18(12):2213-2215.
[7] 王耀勇,田瑶,吴建华,等.载脂蛋白A-Ⅰ、A-Ⅱ和血清淀粉样蛋白A水平变化在肺炎中的意义[J].中国医师进修杂志,2016,39(4):343-345.
[8] Korthagen NM,van Moorsel CH,Zanen P,et al. Evaluation of circulating HC-gp39 levels in idiopathic interstitial pneumonias[J]. Lung,2014,192(6):975-980.
[9] Passamonti F,Vardi DM,Stefanetti V,et al. Rhodococcus equi pneumonia in foals:an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice[J].Vet J,2015,203(2):211-218.
[10] 马卫银,彭韶,张婷. 反复肺炎患儿血清HC-gp39与体液免疫功能的变化及意义[J]. 中国当代儿科杂志,2017,19(4):425-429.
[11] 林文朝.肺炎支原体肺炎肺外器官受累情况及其预后影响因素分析[J].当代医学,2014,20(11):49-49,50.
[12] 孙海斌,王晓蕾,李征瀛,等.ROC曲线评价血清人软骨糖蛋白39在儿童社区获得性肺炎诊断和预测并发症中的应用[J].东南大学学报:医学版,2014,33(6):768-771.

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支原体肺炎患儿的血清淀粉样蛋白A及人软骨糖蛋白-39水平变化与及预后的相关性分析

Analysis of serum amyloid A and human cartilage glycoprotein-39 levels in children with mycoplasmal pneumonia and the correlation with prognosis

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