关键词: 早产儿, 甲状腺激素, 危重症, 相关性

Abstract: Objective To analyze the correlation between serum thyroid hormone level and disease severity of preterm infants, so as to provide reference for early screening of critically ill infants. Methods A total of 209 preterm infants in Children's Hospital of Jiangxi Province from March 2018 to June 2019 were selected as study objects, and were divided into critically-ill group(n=23), recovery group (n=60) and non-critical group(n=126) according to the severity of disease.Serum levels of FT3, FT4 and TSH on the 7th and 14th day after birth were tested, and the difference of thyroid hormone concentrations on the 7th and 14th day(△FT3、△FT4、△TSH) was calculated.The association of disease with FT3, FT4, TSH, △FT3, △FT4 and △TSH was analyzed. Results There were no differences in gestational age, weight and gender among the three groups of premature infants(P＞0.05).The concentrations of FT3 and FT4 in the critically ill group and recovery group on the 14th day after birth were higher than those on the 7th day after birth, but the concentrations of FT3 in the critically ill premature infants on the 7th day and 14th day were lower than those in the recovery group and non-critically ill group(P＜0.05).△FT3 of the critically-ill group was lower than that of the recovery group and the non-critical group, △FT4 of the non-critical group was significantly lower than that of the other two groups(F=3.727, 11.860, P＜0.05).And △TSH was not significantly different among the three groups(F=1.082, P＞0.05). Conclusions The concentration of FT3 is closely related to the severity of the disease.And the more severe the disease, the lower the concentration of FT3.

Key words: preterm infant, thyroid hormone, critically ill, correlation