关键词: 快速生长, 儿童, 空腹血糖, 血脂

Abstract: Objective To assess the impact of rapid growth during infancy or childhood on serum levels of glucose and lipids at the age of 6 years old,to provide theoretical basis for the effective prevention of metabolic disease in childhood and adulthood. Methods From March 1st, 2017 to June 30th, 2018, a total of 9 719 children aged six years in senior class of 50 municipal kindergartens in Tianjin were selected by a cross-sectional survey. Body weight, height, serum levels of glucose, total cholesterol and triglycerides were measured. The anthropometry data at birth and at 1 year old was retrospectively collected. Rapid growth was defined as standard deviation higher than 0.67 of weight gain from two measurements. Then the correlations of rapid growth at 0- to 2-year-old, 2-to 5-year-old with blood glucose and lipids levels were analyzed. Results Compared with children with non-rapid growth, children with rapid growth during infancy (from birth up to 2 years old) and childhood (2 to 5 years old) had higher serum levels of glucose [(4.78±0.45)mmol/L vs. (4.66±0.51)mmol/L] and triglycerides [(0.96±0.44)mmol/L vs. (0.83±0.34)mmol/L] at 6 years old (P<0.05). Logistics regression analysis indicated that children with rapid growth during infancy(OR=1.343, 95%CI: 1.040—1.733) and childhood(OR=2.697, 95%CI: 2.038—3.570) increased the risk for higher level of triglycerides(P<0.05). Conclusions Rapid growth in early childhood is associated with both serum glucose and lipids levels at 6 years old. Thus appropriate weight gain should be emphasized to children.

Key words: rapid growth, children, serum glucose, lipids