关键词: 孤独症谱系障碍, 孤独症, 影响因素, 危险因素, 儿童

Abstract: Objective To investigate the risk factors affecting children with autism spectrum disorder (ASD) and to offer basis for etiology,pathogenesis and prevention for ASD. Methods A total of 80 children with ASD and 80 normal children were investigated in this case-control study.Risk factors were obtained through self-administered questionnaires which were completed by parents. Results Logistic analysis according to their contributive values showed the risk factors were postterm delivery (OR=20.396,P<0.01),atificial feeding (OR=7.567,P<0.01),neonatal jaundice (OR=7.234,P<0.01),hypoxia (OR=6.411,P<0.05),risk factors during pregnancy (OR=3.354,P<0.01),plastic toys (OR=3.115,P<0.01) and mother's introversion character (OR=2.086,P<0.05).However,regular family education was the protect factor. Conclusions The environment factors,the unfavorable events in pregnant and delivery,the neonatal and developmental phase could increase the incidence of autism spectrum disorder.Some effective should be taken to control these risk factors.

Key words: autism spectrum disorder, autism, influencing factor, risk factor, childhood