被动吸烟孕母血浆白细胞介素-6和白细胞介素-10与早产关系的临床研究

doi:10.11852/zgetbjzz2015-23-11-17

中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (11): 1175-1177.DOI: 10.11852/zgetbjzz2015-23-11-17

被动吸烟孕母血浆白细胞介素-6和白细胞介素-10与早产关系的临床研究

程贵辉¹,崔其亮²,邱其周¹,熊伟¹,杨永玲¹,肖毅¹

1 广州医科大学附属深圳沙井医院新生儿科,广东深圳 518104;
2 广州医科大学附属第三医院儿科中心,广东广州 510150

收稿日期:2015-05-13 发布日期:2015-11-10 出版日期:2015-11-10
通讯作者: 崔其亮,E-mail:cuiqiliiang@21cn.com
作者简介:程贵辉(1979-),男,广东人,主治医师,在读研究生,主要研究方向为新生儿危重症。

Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.

CHENG Gui-hui¹,CUI Qi-liang²,QIU Qi-zhou¹,XIONG Wei¹,YANG Yong-ling¹,XIAO Yi¹

1 Department of Pediatrics,Shajing Hospital Affiliated to Guangzhou Medical University,Shenzhen,Guangdong 518104,China;
2 The Third Affiliated Hospital of Guangzhou Medical University Guangzhou,Guangdong 510150,China

Received:2015-05-13 Online:2015-11-10 Published:2015-11-10
Contact: CUI Qi-liang,E-mail:cuiqiliang@21cn.com

摘要/Abstract

摘要： 目的研究被动吸烟孕妇血浆白细胞介素6(interleukin-6,IL-6)和白细胞介素10(interleukin-10,IL-10)在孕期的变化,探讨其与早产之间的关系。方法选取155例早产孕妇(28~36⁺⁶周)为研究组,并根据有无存在被动吸烟分成两组,研究组1为被动吸烟组,研究组2在妊娠期间无被动吸烟或吸烟;同时选取82例对照组孕妇(妊娠期无被动吸烟或吸烟且最后足月分娩的产妇)。采用酶联免疫吸附法,测定研究组1、2孕妇及对照组孕妇在相应孕周时的血浆IL-6和IL-10浓度。结果研究组1孕妇血浆IL-6浓度较研究组2和对照组明显升高(P<0.05);而研究组1孕妇IL-10浓度较在研究组2降低,但其变化无显著意义(P>0.05);研究组孕妇IL-10较对照组明显下降(P<0.05)。结论孕期被动吸烟可致IL-6明显升高,及IL-10呈下降趋势,可能参与了被动吸烟引发早产高风险的机制,增加早产的发生风险。

关键词: 被动吸烟, 白细胞介素-6, 白细胞介素-10, 早产

Abstract: Objective To study pregnancy changes of plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) in the passive smoking pregnant women to explore it's relationship with premature. Methods According to the exist of passive smoking,155 cases of premature pregnant (28~36⁺⁶ weeks) of study group were divided into two groups,study group 1 as passive smoking group,study group 2 during pregnancy without passive smoking or smoking; and 82 cases of pregnant women were selected as the control group (no passive smoking or smoking during pregnancy and the final normal term labor).Maternal plasma IL-6 and IL-10 concentrations were tested by enzyme-linked immunosorbent assay during 28~36⁺⁶ weeks' gestation. Results Maternal plasma IL-6 concentration of study group 1 were significantly higher than that of study group 2 and control group(P<0.05);But maternal plasma IL-10 concentration of study group 1 was lower than that of the study group 2,but had no significant difference(P>0.05);and maternal plasma IL-10 concentration of study group was significantly lower than that of control group(P<0.05). Conclusion Passive smoking during pregnancy can cause IL-6 increased significantly,and IL-10 decreased,which may participate in the mechanism of passive smoking causing premature high-risk,to increase the risk of preterm delivery.

Key words: passive smoking, interleukin-6, interleukin-10, premature

中图分类号:

R179

程贵辉,崔其亮,邱其周,熊伟,杨永玲,肖毅. 被动吸烟孕母血浆白细胞介素-6和白细胞介素-10与早产关系的临床研究[J]. 中国儿童保健杂志, 2015, 23(11): 1175-1177.

CHENG Gui-hui,CUI Qi-liang,QIU Qi-zhou,XIONG Wei,YANG Yong-ling,XIAO Yi. Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.[J]. journal1, 2015, 23(11): 1175-1177.

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参考文献

[1] 李娟,王庆红,吴红敏,等.2005年中国城市产科新生儿出生状况调查[J].中国当代儿科杂志,2012,14(1):7-10.
[2] Ting-Jung K,Li-Yi T,Li-Ching C,et al.Parental smoking during pregnancy and its association with low birth weight,small for gestational age,and preterm birth offspring:a birth cohort study[J].Pediatrics and Neonatology,2014,55:20-27.
[3] 丁鹏.被动吸烟及母亲CYP1A1、GSTM1、GSTT1基因多态性与早产关系的病例对照研究[D].广州:中山大学,2010.
[4] 许正先,陈维清.早产危险因素的病例对照研究[J].中国妇幼保健,2012,27(35):5687-5690.
[5] Castro P,Legora-Machado A,Cardilo-Reis L,et al.Inhibition of interleukin-1 beta reduces mouse lung inflammation induced by exposure to cigarette smoke[J].Eur J Pharmacol,2004,498(1-3 ):279-286.
[6] Wilson KM,Wesgate SC,Pier J,et al.Secondhand smoke exposure and serum cytokine levels in healthy children[J].Cytokine,2012,60(1):34-37.
[7] Chiu YH,Spiegelman D,Doekery DW,et al.Secondhand smoke exposure and inflammatory markers in nonsmokers in the trucking industry[J].Environ Health Pempect,2011,119(9):1294-1300.
[8] Lavi S,Eric HY,Prasad A,et al.Smoking is associated with epicardial coronary endothelial dys function and elevated white blood cell count in patientc with chest pain and early coronary artery disease[J].Circulation,2007,115:2621-2627.
[9] Goedhart G,Snijders AC,Hesselink AE,et al.Maternal depressive symptoms in relation to perinatal mortality and morbidity:results from a large multiethnic cohort study[J].Psychosom Med,2010,72(8):769-776.
[10] 张博林,史慧静,王群,等.孕期被动吸烟与孕产期母婴健康的关联[J].中国妇幼保健,2014,29(9):1384-1387.
[11] Zeyrek D,Ozturk E,Ozturk A,et al.Decreased thymus size in fullterm newbron infants of smoking mothers[J].Med Sci Monit,2008,14(8):423-426.
[12] Wikstrom AK,Cnattingius S,Galanti MR,et al.Effect of Swedish snuff (snus) on preterm birth[J].BJOG,2010,117(8):1005-1010.
[13] Hebisch G,Neumaier-Wagner PM,Huch R,et al.Maternal serum interleukin-1 beta,-6 and-8 levels and potential determinants in pregnancy and peripartum[J].J Perinat Med,2004,32(6):475-480.
[14] Turhan NO,Karabulut A,Adam B,et al.Maternal serum interleukin-6 levels in preterm labor.prediction of admission-to-delivery interval[J].Perinat Med,2000,28(2):133-134.
[15] 牛中正,谢传波,丁鹏,等.妊娠期被动吸烟与母亲血清和脐带血清炎性因子的关系[J].中华疾病控制杂志,2014,18(3):190-193.
[16] Ekerfelt C,Lidstrom C,matthiesen L,et al.Spontaneous secretion of interleukin-4,interleukin-10 and interferon-gamma by first trimester decidual mononuclear cells[J].Am J Reprod Immunol,2002,47(3):159-166.
[17] Moore KM,Waal Malefyt R,Coffman RL,et al.Interleukin-10 and the interleukin-10 receptor[J].Annu Rev Immunol,2001,19:683-765.
[18] Hanna N,Hanna I,Hleb M,et al.Cestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts[J].The Journal of Immunology,2000,164(11):5721-5728.

被动吸烟孕母血浆白细胞介素-6和白细胞介素-10与早产关系的临床研究

Clinical study of passive smoking pregnant maternal plasma interleukin-6 and interleukin -10 and preterm.

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