关键词: 先天性甲状腺功能减退症, 促甲状腺素, 筛查, ROC曲线, 切值

Abstract: Objective To know the distribution of TSH and incidence of neonatal congenital hypothyroidism(CH),and study the screening cut-off points of the thyroid-stimulating hormone(TSH)in Anqing. Methods The neonatal screening data about 59 295 newborns in Anqing were analyzed and the TSH cut-off points were calculated by method of percentiles and Receiver Operating Characteristic (ROC)curve,then,the incidence of sufferers was analyzed by different cut-off points. Results The distribution of the neonatal screening data was deflection,P₅₀ was 2.52 mU/L,P₉₉ was 8.94 mU/L.Combined with ROC curve,the cut-off points of our lab was 8.12 mU/L. Conclusions Different cut-off points effect the consequences of the neonatal screening.It is important to establish the suitable cut-off points with ROC curve based on lab.

Key words: congenital hypothyroidism, thyrotropic-stimulating hormone, neonatal screening, ROC curve, cut-off points