关键词: 高糖饮食, 学习记忆, 抑郁

Abstract: Objective To discuss the effect of high-sugar diets on learning,memory and emotion of young rats,and whether the calcium supply could produce the improve effect. Methods The young rats (postnatal days 30～35) were as the research object.They were treated continuously with high-sugar diet for three weeks,Morris water maze tested the ability of learning and memory,forced swim test was used to examine the depressive behavior,elevated plus maze was used to test anxiety-like behavior.Meanwhile,the changes of serum calcium content following high sugar diet with calcium supply and relationship were observed between calcium and behaviors above. Results In Morris water maze,escape latency of young rats[(81.2±7.9)s,(76.8±8.4)s,(67.4±6.9)s and (61.3±6.4)s] sprolongs and frequency of crossing platform(1.4±0.6) decreased significantly after continuously treating with high sugar diet,and calcium supply did not produce obvious improvement effect on these indexes; floating latency[(99.5±10.8)s] was shortened and floating time[(432.8±11.2)s] was significantly prolonged in forced swimming test,which almost returned to the normal level after calcium supplying.However,all of the indexes of the elevated plus maze had no any changes after high sugar diets treating and calcium supplying. Conclusions High-sugar diet results in a decreased learning and memory and depressive behavior,moderate calcium supply can improve the depressive symptom,but is unhelpful to the learning and memory.

Key words: high sugar diet, learning and memory, depression