关键词: 早产儿, 母乳喂养, 体格生长, 营养, 母乳强化剂

Abstract: Objective To explore the effects of different milk feeding pattern on the growth and development of preterm infants. Method 247 cases of 800~1 500 g preterm infants from Jan.2011 to Dec.2015 were divided into mother breast milk group 78 cases (group A),the mother breast milk + human milk fortifier (HMF) 75 cases (group B),without mother breast milk accepting donor breast milk + HMF group 49 cases (group C) and without mother breast milk accepting the premature formula group 45 cases (group D).All infants were taken active feeding measures,with observation of full enteral feeding,physical growth and development,complications,the average length of hospital stay,etc. Results Mother breast milk group were lower than other three groups in physical development indexes such as the head circumference,weight and body length,time to enteral feeding at 100 Cal/(kg·d),regain birth weight time,while venous nutrition time was longer than other groups (P<0.05).There was no statistically significant difference between the other three groups.Preterm formula group had higher risk of infection within 1 year after discharge than other groups (P<0.05).There was no statistically significant difference in incidence of cholestasis,length of hospital stay,feeding intolerance and incidence of EUGR between the four groups (P>0.05). Conclusion The preterm birth mother milk + HMF is the best milk feeding pattern for preterm infants,followed by donor breast milk + HMF and preterm formula.   

Key words: preterm infant, breast feeding, physical growth, nutrition, human milk fortifier