关键词: D-二聚体, 新生儿窒息, 新生儿感染性肺炎, 新生儿呼吸窘迫综合征, 新生儿病理性黄疸

Abstract: Objective To investigate the clinical significance of plasma D-dimer level in early neonatal common diseases. Methods Venous blood samples were collected from 300 cases of neonatal common diseases (experimental group) and 50 cases of healthy newborns (control group).The level of D-dimer was tested by ELISA. Results Compare with the healthy control group (320.4±145.5),D-dimer levels of mild (1 167.5±683.7) and severe (5 399.5±3 123.3) neonatal asphyxia groups were both significantly increased,especially in severe neonatal asphyxia group.Compared with healthy control group (320.4±145.5),the D-dimer levels of neonatal pneumonia group (2 406.8±1 559.5) significantly increased.The D-dimer levels of neonatal respiratory distress syndrome (NRDS) group (1 975.6±1 205.66) and neonatal jaundice group (401.13±229.15) significantly increased compared with healthy control group (320.44±145.58),while neonatal wet lung disease group (316.92±174.29) had no statistically significant difference. Conclusion The plasma D-dimer testing has some practical value for diagnosis and prognosis of newborns hypercoagulable state and thrombotic disease.   

Key words: D-dimer, neonatal asphyxia, neonatal pneumonia, neonatal respiratory distress syndrome, neonatal jaundice