小肠细菌过度生长研究进展

doi:10.11852/zgetbjzz2017-25-08-11

摘要/Abstract

摘要： 小肠细菌过度生长(SIBO)是一种器质性或功能性原因引起的小肠细菌数量增加和/或种类改变的临床综合征,表现为腹痛、腹胀、腹泻和营养不良等,与儿童多种疾病相关,影响儿童的健康和生长发育。目前对于儿童SIBO重视不足,本文将从流行病学、发病机制及危险因素、检测和治疗方法等多个方面进行综述。

关键词: 小肠细菌过度生长, 诊断, 治疗

Abstract: Small intestinal bacterial overgrowth(SIBO)is a condition characterized by the presence of abnormal diversity and/or excessive numbers of bacterium in the small intestine due to a variety of functional or organic reasons,with a myriad of symptoms including abdominal pain,bloating,diarrhea,nutritional deficiencies,and so on.SIBO is found in a wide variety of childhood diseases and conditions and affects their health and growth.However,SIBO in children is lack of sufficient consideration.The epidemiology,pathogenesis and risk factors,diagnositic tests and therapy of SIBO are reviewed in this paper

Key words: small intestinal bacterial overgrowth, diagnosis, therapy

中图分类号:

R179

刘作静,段丽萍. 小肠细菌过度生长研究进展[J]. 中国儿童保健杂志, 2017, 25(8): 793-795.

LIU Zuo-jing,DUAN Li-ping. Advances in research on small intestinal bacterial overgrowth[J]. journal1, 2017, 25(8): 793-795.

参考文献

[1] Quigley EM,Quera R.Small intestinal bacterial overgrowth:roles of antibiotics,prebiotics,and probiotics[J].Gastroenterology,2006,130(Suppl2):78-90.
[2] Krajicek EJ,Hansel SL.Small intestinal bacterial overgrowth:A primary care review[J].Mayo Clin Proc,2016,91(12):1828-1833.
[3] Donowitz JR,Haque R,Kirkpatrick BD,et al.Small intestine bacterial overgrowth and environmental enteropathy in bangladeshi children[J].MBio,2016,7(1):e02102-e02115.
[4] Sieczkowska A,Landowski P,Kamińska B,et al.Small bowel bacterial overgrowth in children[J].J Pediatr Gastroenterol Nutr,2016,62(2):196-207.
[5] Grace E,Shaw C,Whelan K,et al.Review article:small intestinal bacterial overgrowth-prevalence,clinical features,current and developing diagnostic tests,and treatment[J].Aliment Pharmacol Ther,2013,38(7):674-688.
[6] Sieczkowska A,Landowski P,Zagozdzon P,et al.Small bowel bacterial overgrowth associated with persistence of abdominal symptoms in children treated with a proton pump inhibitor[J].J Pediatr,2015,166(5):1310-1312.
[7] Fridge JL,Conrad C,Gerson L,et al.Risk factors for small bowel bacterial overgrowth in cystic fibrosis[J].J Pediatr Gastroenterol Nutr,2007,44(2):212-218.
[8] Belitsos PC,Greenson JK,Yardley JH,et al.Association of gastric hypoacidity with opportunistic enteric infections in patients with AIDS[J].J Infect Dis,1992,166(2):277-284.
[9] Roland BC,Ciarleglio MM,Clarke JO,et al.Low ileocecal valve pressure is significantly associated with small intestinal bacterial overgrowth (SIBO)[J].Dig Dis Sci,2014,59(6):1269-1277.
[10] Gutierrez IM,Kang KH,Calvert CE,et al.Risk factors for small bowel bacterial overgrowth and diagnostic yield of duodenal aspirates in children with intestinal failure:a retrospective review[J].J Pediatr Surg,2012,47(6):1150-1154.
[11] Erdogan A,Rao SS,Gulley D,et al.Small intestinal bacterial overgrowth:duodenal aspiration vs glucose breath test[J].Neurogastroenterol Motil,2015,27(4):481-489.
[12] Pyleris E,Giamarellos-Bourboulis EJ,Tzivras D,et al.The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture:relationship with irritable bowel syndrome[J].Dig Dis Sci,2012,57(5):1321-1329.
[13] Posserud I,Stotzer PO,Bjrnsson ES,et al.Small intestinal bacterial overgrowth in patients with irritable bowel syndrome[J].Gut,2007,56(6):802-808.
[14] Pimentel M.Breath testing for small intestinal bacterial overgrowth:should we bother[J].Am J Gastroenterol,2016,111(3):307-8.
[15] Ghoshal UC.How to interpret hydrogen breath tests[J].J Neurogastroenterol Motil,2011,17(3):312-317.
[16] Ghoshal UC,Srivastava D.Irritable bowel syndrome and small intestinal bacterial overgrowth:meaningful association or unnecessary hype[J].World J Gastroenterol,2014,20(10):2482-2491.
[17] Gasbarrini A,Corazza GR,Gasbarrini G,et al.Methodology and indications of H2-breath testing in gastrointestinal diseases:the Rome Consensus Conference[J].Aliment Pharmacol Ther,2009,29(Suppl 1):1-49.
[18] 刘作静,魏慧,段丽萍,等.肠易激综合征患者合并小肠细菌过度生长的临床特征及利福昔明治疗效果初探[J].中华医学杂志,2016,96(24):1896-1902.
[19] Shah SC,Day LW,Somsouk M,et al.Meta-analysis:antibiotic therapy for small intestinal bacterial overgrowth[J].Aliment Pharmacol Ther,2013,38(8):925-934.
[20] Rezaie A,Pimentel M,Rao SS.How to test and treat small intestinal bacterial overgrowth:an evidence-based approach[J].Curr Gastroenterol Rep,2016,18(2):8.
[21] Iorio N,Malik Z,Schey R.Profile of rifaximin and its potential in the treatment of irritable bowel syndrome[J].Clin Exp Gastroenterol,2015,8:159-167.
[22] Scarpellini E,Giorgio V,Gabrielli M,et al.Rifaximin treatment for small intestinal bacterial overgrowth in children with irritable bowel syndrome[J].Eur Rev Med Pharmacol Sci,2013,17(10):1314-1320.
[23] Collins BS,Lin HC.Double-blind,placebo-controlled antibiotic treatment study of small intestinal bacterial overgrowth in children with chronic abdominal pain[J].J Pediatr Gastroenterol Nutr,2011,52(4):382-386.
[24] Pimentel M,Chang C,Chua KS,et al.Antibiotic treatment of constipation-predominant irritable bowel syndrome[J].Dig Dis Sci,2014,59(6):1278-1285.
[25] Ockeloen LE,Deckers-Kocken JM.Short-and long-term effects of a lactose-restricted diet and probiotics in children with chronic abdominal pain:a retrospective study[J].Complement Ther Clin Pract,2012,18(2):81-84.
[26] Zhong C,Qu C,Wang B,et al.Probiotics for preventing and treating small intestinal bacterial overgrowth:A meta-analysis and systematic review of current evidence[J].J Clin Gastroenterol,2017,51(4):300-311.
[27] Khalighi AR,Khalighi MR,Behdani R,et al.Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO)--a pilot study[J].Indian J Med Res,2014,140(5):604-608.
[28] Hegar B,Hutapea EI,Advani N,et al.A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole[J].J Pediatr (Rio J),2013,89(4):381-387.
[29] Lai PK,Roy J.Antimicrobial and chemopreventive properties of herbs and spices[J].Curr Med Chem,2004,11(11):1451-1460.
[30] Chedid V,Dhalla S,Clarke JO,et al.Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth[J].Glob Adv Health Med,2014,3(3):16-24.
[31] Pimentel M,Constantino T,Kong Y,et al.A 14-day elemental diet is highly effective in normalizing the lactulose breath test[J].Dig Dis Sci,2004,49(1):73-77.
[32] Deng Y,Misselwitz B,Dai N,et al.Lactose Intolerance in Adults:Biological Mechanism and Dietary Management[J].Nutrients,2015,7(9):8020-8035.