关键词: 染色体异常, 智力障碍, Down综合征

Abstract: Objective To analyse the incidence of abnormal karyotype of the mental retardation (MR) children in Qiqihar area. Method A total of 260 cases of MR children were used peripheral blood cell culture method and G banding karyotype detection. Results Among 260 cases of MR children,abnormal karyotypes detection rate was 41.54%(108/260).Among them,standard 21-trisomy syndrome:50 cases,detection rate was 46.29%(50/108).Strueutarl abnormalities of 11 cases were detected with detection rate of 10.18% (11/108). Conclusions MR children and abnormal karyotypes are closely related,mainly with abnormal karyotype of chromosome 21-trisomy syndrome.It is important to analyze the chromosome karyotype of the MR of children.

Key words: abnormal karotype, mental retardation, Down syndrome