关键词: 孤独症谱系障碍, 淀粉样前体蛋白, 脑源性生长因子, 注意缺陷多动障碍, 智力障碍

Abstract: Objective To analyze the specificity of amyloid precursor protein (APP) and brain derived neurotrophic factor (BDNF) in peripheral blood in children with autism spectrum disorder (ASD), so as to explore the biomarkers for early diagnosis of ASD. Method A total of 103 ASD children,25 children with intellectual disability (ID),25 children with attention deficit hyperactivity disorder (ADHD) and 78 healthy children in Hubei Provincial Maternal and Child Health Care Hospital were enrolled in this study from January 2013 to December 2016. And the plasma total sAPP, sAPP-α, sAPP-β and brain-derived neurotrophic factor (BDNF) of participants were tested by sensitive enzyme-linked immunosorbent assay method, and were compared among those four groups. Results The levels of sAPP and sAPP-α among ASD, ID, ADHD and normal control groups were significantly different (Z=86.17,39.01,both P＜0.001), while the difference on the levels of sAPP-β and BDNF among those four groups were not significant (both P＞0.05). Conclusions Considering the specific change of APP in ASD children, APP may be a promising biomarker in the early diagnosis of ASD.

Key words: autism spectrum disorder, amyloid precursor protein, brain derived neurotrophic factor, attention deficit hyperactivity disorder, intellectual disability