关键词: 辅助受孕, 新生儿情况, 智力发育, 对照研究

Abstract: Objective To compare the neonatal outcomes and the intelligence development at 8 years old in children born after assisted conception with a control group of children conceived naturally.Methods A prospective control study was performed. The experimental group were children born after assisted conception, the control group were children born after natural conception. The mothers were invited to participate at 28 weeks of gestation and were followed up to delivery.Related data were collected and registered by trained professionals.The children of two groups were followed up to 8 years old. A formal developmental assessment was conducted with the CDCC Scales of Children Development when they were under 3 years old and a formal intelligence assessment was done with the Stanford-Binet Intelligence Tests when they were over 3 years old. Results In the assisted conception group, the incidence rates of twins preterm birth, low birth weight and admission to Neonatal Intensive Care Unit(NICU) were significantly higher than those of the control group.But these differences seemed to disappear when only singletonswere compared between the two groups.And the differences were not significant on neonatal outcomes in infants conceived by different Methods of assisted conception (IVF-ET、ICSI、FET). No statistically significant differences were found in the intelligence development at 8 years old between the experimental group and the control group. Conclusions Neonatal outcomes after assisted conception is worse than natural conception, mainly due to the large proportion of multifetal births after assisted conception. Followed up to 8 years old, the level of intelligence development in children born after assisted conception is normal.And the growth and development of the offsprings by using different ways of assisted conception are similiar.

Key words: assisted conception, neonatal outcomes, intelligence development, control study