关键词: 儿童, 食物不耐受, 抽动症

Abstract: Objective To describe the status of food hypersensitivity in children with tourette syndrome(TS) by food intolerance test, and to analyze the relationship between food intolerance and TS. Methods Retrospective analysis was used to enroll 61 TS patients from January 2016 to October 2017, including 39 boys and 22 girls. And 50 healthy children over four years old were enrolled in control group, including 28 boys and 22 girls. The enzyme linked immunosorbent assay(ELISA) method was applied to detect the serum specific antibodies IgG levels of 14 kinds of food allergens in the two group of children, and the differences were compared. Results The food intolerance rate was 98.4%(60/61) in TS children, while 78.0%(39/50) in healthy children. And the difference on food intolerance rate between the two groups was significant(P＜0.01). The rates of multiple kinds of food intolerance in TS children were significantly higher than those in healthy children (one type of food intolerance:23.0% vs. 34.0%;two types of food intolerance:24.6% vs. 38.0%;three types of food intolerance:34.4% vs. 6.0%;four types of food intolerance:16.4% vs. 0%,all P＜0.01). Eggs and milk were the main types of food intolerances in two groups, but the intolerance in TS children was more serious than that in the healthy children (IgG+++:36.7% vs.19.7%, P＜0.001). Conclusion Food intolerance test is a useful method for TS children to find food allergens, thereby providing guidance for children′s diet in order to promote children′s healthy development.

Key words: food intolerance, tourette syndrome, children