关键词: 布洛芬, 静脉导管未闭, 婴儿, 早产

Abstract: Objective To test the feasibility of oral ibuprofen treatment in preterm infants with patent ductus venosus(PDV). Methods A total of 90 neonates hospitalized with neonatal jaundice and diagnosed with PDV by echocardiography within 24 hours after birth were enrolled in this study from March 2016 to July 2017.And participants were randomly divided into the treatment group(n=45) and control group(n=45).The treatment group was orally administered ibuprofen of 10 mg/kg within 24 hours after birth, followed 24 hours later by the second dose of 5 mg/kg and 48 hours later by the third dose of 5 mg/kg.While the control group was treated with placebo(normal saline) of 1 ml/kg, followed 24 hours later by the second dose of 0.5 ml/kg and 48 hours later by the third dose of 0.5ml/kg.The total bilirubin (TB), direct bilirubin (DBIL), indirect bilirubin (IBIL) and serum ammonia levels were tested before and after treatment in two groups.The two groups were examined by echocardiography after treatment, also the efficacy and adverse reactions of the two groups were observed after treatment. Results 1)The rate of closure of ductus venosus in the treatment group was significantly higher than that in the control group (77.8% vs.22.2%, P＜0.01).2)The levels of TB, DBIL, IBIL and blood ammonia after treatment in the treatment group were significantly lower than those in the control group (P＜0.01).3) In terms of adverse reactions,the differences on positive rate of fecal occult blood, the rates of intracranial hemorrhage, necrotizing enterocolitis,oliguria and feeding intolerance between two groups were not significant (all P＞0.05).Also, the levels of platelet and creatinine in two groups were not significantly different (P＞0.05). Conclusion Oral administration of ibuprofen can effectively promote the closure of PDV with clinical application of relative safety.

Key words: ibuprofen, patent ductus venosus, infants, premature