不同出生胎龄早产儿的智能发育水平分析

doi:10.11852/zgetbjzz2018-08891

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (4): 429-432.DOI: 10.11852/zgetbjzz2018-08891

不同出生胎龄早产儿的智能发育水平分析

周凤娟, 屠思, 刘贤, 卢锦华, 邱琇

广州医科大学广州市妇女儿童医疗中心出生队列研究室,广东广州 510623

收稿日期:2018-06-24 修回日期:2018-10-21 发布日期:2019-04-20 出版日期:2019-04-20
通讯作者: 邱琇,E-mail:qxiu0161@163.com
作者简介:周凤娟(1983-),女,江西人,硕士学位,主要从事儿童保健工作。
基金资助:
广州市医药卫生科技项目(20161A011023)

Study on the development of intelligence in preterm infants with different gestational ages

ZHOU Feng-juan, TU Si, LIU Xian, LU Jin-hua, QIU Xiu

Division of Birth Cohort Study,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,China

Received:2018-06-24 Revised:2018-10-21 Online:2019-04-20 Published:2019-04-20
Contact: QIU Xiu,E-mail:qxiu0161@163.com

摘要/Abstract

摘要： 目的分析不同出生胎龄早产儿智能发育情况,为早产儿保健提供指导。方法选择自2012年2月-2015年12月在广州市妇女儿童医疗中心儿童保健科接收发育评估的2 579名婴幼儿为观察对象,分为中期早产儿(MPT)组(32^+0/7~33^+6/7周)、晚期早产儿(LPT)(34^+0/7~36^+6/7周) 组、早期足月儿(ET)组(37^+0/7~38^+6/7周)和足月儿(FT)组(39^+0/7~40^+6/7周)。采用Gesell量表对所有研究对象进行神经发育水平评估,并比较各组差异。结果以FT组作为参照,MPT组、LPT组和ET组神经发育迟缓的风险增高,OR值分别为2.38(95%CI:1.18~4.78)、1.63(95%CI:1.07~2.48)、1.42(95%CI:1.12~1.81)。结论中晚期早产儿相比足月儿发生神经发育迟缓的风险比例增高,而早期足月儿同样风险比例增高,孕周与发育迟缓的风险呈现一个剂量效应。

关键词: 早产儿, 发育迟缓, 发育商

Abstract: Objective To analyze the intelligence development of preterm with different gestational ages,in order to provide suggestions for healthcare of premature infants. Methods A total of 2 579 children aged 6-24 months in Guangzhou Women and Children's Medical Center were enrolled in this study from February 2012 to December 2015. And the participants were divided into four groups according to gestational age,including moderate preterm (MPT) (32^+0/7-33^+6/7weeks),late preterm (LPT)(34^+0/7-36⁺⁶weeks),early term (ET)(37^+0/7-38⁺⁶weeks) and full-term (FT)(39^+0/7-41⁺⁶ weeks) infants. Gesell development Scale was used to assess the neurodevelopment of participants,and the difference among four groups were compared. Results Compared with those born full term,the risk of neurodevelopmental delay in MPT(OR=2.38,95%CI:1.18-4.78),LPT(OR=1.63,95%CI:1.07-2.48) and ET(OR=1.42,95%CI:1.12-1.81) infants were much higher. Conclusions Moderate,late and early preterm increase the risk of delayed neurodevelopment proportion compared with full term infants. And an inverse dose-response relationship between gestational age and risk of developmental delay is found in the tested children.

Key words: preterm birth, development delay, developmental quotient

中图分类号:

R179

周凤娟, 屠思, 刘贤, 卢锦华, 邱琇. 不同出生胎龄早产儿的智能发育水平分析[J]. 中国儿童保健杂志, 2019, 27(4): 429-432.

ZHOU Feng-juan, TU Si, LIU Xian, LU Jin-hua, QIU Xiu. Study on the development of intelligence in preterm infants with different gestational ages[J]. Chinese Journal of Child Health Care, 2019, 27(4): 429-432.

参考文献

[1] Blencowe H,Cousens S,Oestergaard MZ,et al.National,regional,and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries:a systematic analysis and implications[J]. Lancet,2012,379(9832):2162-2172.
[2] Zou L,Wang X,Ruan Y,et al.Preterm birth and neonatal mortality in china in 2011[J]. Int J Gynaecol Obstet,2014,127(3):243-247.
[3] Gladstone M,Oliver C,van den Broek N. Survival,morbidity,growth and developmental delay for babies born preterm in low and middle income countries-a systematic review of outcomes measured[J]. PLoS One,2015,10(3):e0120566.
[4] Tsai ML,Lien R,Chiang MC,et al.Prevalence and morbidity of late preterm infants:current status in a medical center of northern Taiwan[J]. Pediatr Neonatol,2012,53(3):171-177.
[5] Stroustrup A,Bragg JB,Andra SS,et al.Neonatal intensive care unit phthalate exposure and preterm infant neurobehavioral performance[J]. PLoS One,2018,13(3):e0193835.
[6] Kirk CM,Uwamungu JC,Wilson K,et al.Health,nutrition,and development of children born preterm and low birth weight in rural rwanda:A cross-sectional study[J]. BMC Pediatr,2017,17(1):191.
[7] Burnett AC,Anderson PJ,Lee KJ,et al.Trends in executive functioning in extremely preterm children across 3 birth eras[J]. Pediatrics,2018,141(1).doi:10.1542/peds.2017-1958.
[8] Woythaler MA,McCormick MC,Smith VC. Late preterm infants have worse 24-month neurodevelopmental outcomes than term infants[J]. Pediatrics,2011,127(3):e622-629.
[9] Romeo DM,Di Stefano A,Conversano M,et al.Neurodevelopmental outcome at 12 and 18 months in late preterm infants[J]. Eur J Paediatr Neurol,2010,14(6):503-507.
[10] Johnson S,Evans TA,Draper ES,et al.Neurodevelopmental outcomes following late and moderate prematurity:A population-based cohort study[J]. Arch Dis Child Fet al Neonatal Ed,2015,100(4):301-308.
[11] Hughes A,Greisen G,Arce JC,et al.Late preterm birth is associated with short-term morbidity but not with adverse neurodevelopmental and physical outcomes at 1 year[J]. Acta Obstet Gynecol Scand,2014,93(1):109-112.
[12] Pierrat V,Marchand-Martin L,Arnaud C,et al.Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in france in 2011:Epipage-2 cohort study[J]. BMJ,2017,358:3448.
[13] Heinonen K,Eriksson JG,Lahti J,et al.Late preterm birth and neurocognitive performance in late adulthood:A birth cohort study[J]. Pediatrics,2015,135(4):e818-825.
[14] 黄海燕,陆岸锋,黄国盛,等. 早产儿生后24个月龄的神经心理发育研究[J]. 中国儿童保健杂,2018,26(4):424-426.
[15] Delnord M,Blondel B,Prunet C,et al.Are risk factors for preterm and early-term live singleton birth the same? A population-based study in france[J]. BMJ Open,2018,8(1):e018745.
[16] Seikku L,Gissler M,Andersson S,et al.Asphyxia,neurologic morbidity,and perinatal mortality in early-term and postterm birth[J]. Pediatrics,2016,137(6).doi:10.1542/peds.2015-3334.
[17] Chan E,Leong P,Malouf R,et al.Long-term cognitive and school outcomes of late-preterm and early-term births:a systematic review[J]. Child Care Health Dev,2016,42(3):297-312.
[18] Murray SR,Shenkin SD,McIntosh K,et al. Long term cognitive outcomes of early term (37-38 weeks) and late preterm (34-36 weeks) births:a systematic review[J]. Wellcome Open Res,2017,2:101.
[19] Dueker G,Chen J,Cowling C,et al.Early developmental outcomes predicted by gestational age from 35 to 41weeks[J]. Early Hum Dev,2016,103(1):85-90.

不同出生胎龄早产儿的智能发育水平分析

Study on the development of intelligence in preterm infants with different gestational ages

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