关键词: 25-(OH)D₃, 湿疹, 婴儿, 过敏性疾病

Abstract: Objective To make clear the correlation between serum 25-(OH)D₃level and the development of eczema in early life of infants,so as to provide evidence for vitamin D supplementation in early infancy. Methods Totally 605 infants who took physical examination inSuzhou Municipal Hospital were recruited in this study from November 2016 to October 2017.The baseline data were collected by questionnaires survey,and SCORAD table was used to assess the severity of eczema.The level of 25-(OH)D₃was tested by immune colloidal gold chromatography through blood samples collected from tip of small fingers. Results The average level of 25-(OH)D₃in 605 infants was (28.48±6.10)ng/ml.Totally 457 children developed eczema(75.5%),of whom 421(65.9%) children were mild,35(5.8%) children were moderate,and one(0.2%) child developed severe eczema.The levels of 25-(OH)D₃(F=21.75,P<0.001)and the incidence rate of eczema(χ²=16.01,P=0.014) in different seasons were significantly different.The level of 25-(OH)D₃ was lowest in winter,but risk of eczema was highest in winter.Moreover,the SCORAD was significantly higher in spring (Z=-3.94, P＜0.001) and winter (Z=-2.72,P=0.039) than that in summer.There was no significant difference on the incidence of eczema among different 25-(OH)D₃ level groups,but the level of 25-(OH)D₃was related to the severity of eczema.The risk of moderate to sever eczema increased with the level of 25-(OH)D₃ (OR=1.063,95% CI:1.001-1.129,P=0.045),while infants with severe eczema had lower rate of vitamin D intake behavior than infants with mild eczema(OR=0.365,95%CI:0.179-0.741,P=0.005).Allergic history of parent increased the risk for severe eczema(OR=2.857,95%CI:1.399-5.837, P=0.004). Conclusion The level of 25-(OH)D₃ is higher in infants with severe eczema,but those who take vitamin D supplementation are less.Further researches are warranted to explore the underlying reasons for this discrepancy.

Key words: 25-(OH)D₃, eczema, infant, allergy diseases