儿童维生素A全球干预进展

doi:10.11852/zgetbjzz2019-1116

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (6): 649-652.DOI: 10.11852/zgetbjzz2019-1116

儿童维生素A全球干预进展

杨帆, 李廷玉

重庆医科大学附属儿童医院儿童保健科,儿童发育疾病研究教育部重点实验室;国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,认知发育与学习记忆障碍转化医学重庆市重点实验室,儿童营养与健康重庆市重点实验室,重庆 400014

收稿日期:2019-09-26 发布日期:2020-06-10 出版日期:2020-06-10
通讯作者: 李廷玉,E-mail:tyli@vip.sina.com
作者简介:杨帆(1995-),女,山西人,住院医师,硕士研究生在读,主要研究方向为儿童营养健康与发育。
基金资助:
NSFC面上项目(81771223) ;科技基础资源调查专项(2017FY101100;子课题编号2017FY101103)

Progress on global interventions for vitamin A in children

YANG Fan, LI Ting-yu

Department of Child Health Care,Children′s Hospital of Chongqing Medical University;Ministry of Education Key;Laboratory of Child Development and Disorders;National Clinical Research Center for Child Health and Disorders;China International Science and Technology Cooperation base of Child development and Critical Disorders;Children′s Hospital of Chongqing Medical University,Chongqing,P.R China.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders;Chongqing Key Laboratory of Child Health and Nutrition,Chongqing 400014,China

Received:2019-09-26 Online:2020-06-10 Published:2020-06-10
Contact: LI Ting-yu,E-mail:tyli@vip.sina.com

摘要/Abstract

摘要： 维生素A是人体内重要的微量营养素之一,维生素A缺乏症是导致儿童可预防性失明的主要原因,并增加了严重感染导致疾病和死亡的风险。在大多数发展中国家,维生素A缺乏仍然是重要的公共卫生问题。虽然维生素A的来源多样,补充方式也有多种,但就国家及国际层面而言,缺乏较新的政策指导维生素A的干预。故而在分析全球最新维生素A缺乏症流行趋势及大量干预研究的基础上做出以下综述。

关键词: 维生素A, 干预, 综述, 儿童

Abstract: Vitamin A,as one of the most important micronutrients in the body,its deficiency is the leading cause of preventable blindness in children and increases the risk of serious infections leading to disease and death.Vitamin A deficiency remains a major public health problem in most developing countries.Although there are various sources of Vitamin A and ways of supplementation,there is a lack of relatively new policies to guide vitamin A intervention at the national and international levels.Therefore,the following review is made based on the analysis of the latest global Vitamin A deficiency epidemic trend estimation and a large number of intervention studies.

Key words: vitamin A, intervention, review, children

中图分类号:

R153.2

杨帆, 李廷玉. 儿童维生素A全球干预进展[J]. 中国儿童保健杂志, 2020, 28(6): 649-652.

YANG Fan, LI Ting-yu. Progress on global interventions for vitamin A in children[J]. journal1, 2020, 28(6): 649-652.

参考文献

[1] 李廷玉,黄鸿眉.维生素A缺乏的诊断、治疗及预防[J].中华实用儿科临床杂志,2013,28(19):1519-1520.
[2] World Health Organization.Global prevalence of vitamin a deficiency in populations at risk 1995-2005:Who Global Database on Vitamin a Deficiency[R].Geneva:World Health Organization,2009.
[3] Stevens GA,Bennett JE,Hennocq Q,et al.Trends and mortality effects of vitamin a deficiency in children in 138 low-income and middle-income countries between 1991 and 2013:A pooled analysis of population-based surveys[J].Lancet Glob Health,2015,3(9):528-536.
[4] Song P,Wang J,Wei W,etal.The prevalence of vitamin a deficiency in chinese children:a systematic review and bayesian meta-analysis[J].Nutrients,2017,25,9(12):1285.
[5] World Health Organization.Indicators for assessing vitA deficiency and their application in monitoring and evaluationg intervention programmes[R].Geneva:World Health Organization,1996.
[6] World Health Organization.Guideline:vitamin A supplementation in infants and children 6-59 months of age[R].Geneva:World Health Organization,2011.
[7] United Nations Children′s Fund(UNICEF).Vitamin A Supplementation:a decade of progress[R].New York:UNICEF,2007.
[8] United Nations Children′s Fund(UNICEF).United Nations International children′s fund data:monitoring the situation of children and women[R].New York,UNICEF,2016.
[9] UNICEF.Coverage at a crossroads:New directions for vitamin A supplementation programmes[R].New York:UNICEF,2018
[10] Palmer AC,Diaz T,Noordam AC,et al.Evolution of the child health day strategy for the integrated delivery of child health and nutrition services.[J].Food Nutr Bull,2013,34(4):412-419.
[11] Awasthi S,Peto R,Read S,et al.Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India:DEVTA,a cluster-randomised trial[J].Lancet,2013,381:1469-1477.
[12] Fisker AB,Bale C,Rodrigues A,et al.High-Dose vitamin A with vaccination after 6 months of age:A randomized trial.[J].Pediatrics,2014,134:739-748.
[13] Mason J,Greiner T,Shrimpton R,et al.Vitamin A policies need rethinking[J].Int J Epidemiol,2015,44:283-292.
[14] Imdad A,Mayo-Wilson E,Herzer K,et al.Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age[J].Cochrane Database Syst Rev,2017,3:CD008524.
[15] Wirth JP,Petry N,Tanumihardjo SA,et al.Vitamin a supplementation programs and country-level evidence of vitamin a deficiency[J].Nutrients,2017.9(3):190.
[16] World Health Organization.Guideline:vitamin a supplementation in infants and children 6~59 months of age[R].Geneva:World Health Organization,2011.
[17] Tilman G,Georg L,Andreu P,et al.β-carotene is an important vitamin a source for humans[J].J Nutr,2010,140(12):2268-2285.
[18] Nancy EM,Emily SM,Noor H,et al.Intrinsic and extrinsic factors impacting absorption,metabolism,and health effects of dietary carotenoids[J].Adv Nutr,2018,9(4):465-492.
[19] World Health Organization.Guidelines for food fortification[R].Geneva:World Health Organization,2006.
[20] Global Alliance for Improved Nutrition.Fortifying our future-a snapshot report on food fortification[R].2015.
[21] Dong S,Xia H,Wang F,et al.The effect of red palm oil on vitamin a deficiency:a meta-analysis of randomized controlled trials[J].Nutrients,2017,9(12):1281.
[22] Talsma EF,Brouwer ID,Verhoef H,et al.Biofortified yellow cassava and vitamin A status of Kenyan children:a randomized controlled trial[J].Am J Clin Nutr,2016,103(1):258-267.
[23] Gannon B,Kaliwile C,Arscott SA,et al.Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A:a community-based,randomized placebo-controlled trial[J].Am J Clin Nutr,2014,100(6):1541-1550.
[24] Pinkaew S,Wegmuller R,Wasantwisut E,et al.Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children[J].J Nutr,2014,144(4):519-524.
[25] Rahman AS,Ahmed T,Ahmed F,et al.Double-blind cluster randomised controlled trial of wheat flour chapatti fortified with micronutrients on the status of vitamin A and iron in school-aged children in rural Bangladesh[J].Matern Child Nutr,2015,11(Suppl 4):120-131.
[26] 李廷玉,王蓉,赵勇,等.不同剂量维生素A强化饼干对学龄前儿童健康影响的研究[J].中国儿童保健杂志,2004,12(1):33-36.
[27] Lopez-Teros V,Quihui-Cota L,Méndez-Estrada RO,et al.Vitamin A-fortified milk increases total body vitamin A stores in Mexican preschoolers[J].J Nutr,2013,143(2):221-226.
[28] Keats EC,Neufeld LM,Garrett GS,et al.Improved micronutrient status and health outcomes in low- and middle-income countries following large-scale fortification:evidence from a systematic review and meta-analysis[J].Am J Clin Nutr,2019,109(6):1696-1708.
[29] Hombali AS,Solon JA,Venkatesh BT,et al.,Fortification of staple foods with vitamin A for vitamin A deficiency[J].Cochrane Database Syst Rev,2019,5 CD010068.
[30] 徐娇,霍军生,孙静,等.国内外6～24月龄婴幼儿辅食营养包干预研究[J].中国食品卫生杂志,2017,29(5):550-555.
[31] World Health Organization.Guideline:Use of multiple micronutrient powders for home fortification of foods consumed by infants and children 6~23 months of age[R].Geneva:World Health Organization,2011.
[32] De-Regil LM,Suchdev PS,Vist GE,et al.Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age[J].Cochrane Database Syst Rev,2011; 9:CD008959.
[33] Silva LLS,Augusto RA,Tietzmann DC,et al.The impact of home fortification with multiple micronutrient powder on vitamin A status in young children:A multicenter pragmatic controlled trial in Brazil[J].Matern Child Nutr,2017,13(4).doi:10.1111/mcn.12403.
[34] Oliveira CS,Sampaio P,Muniz PT,et al.Multiple micronutrients in powder delivered through primary health care reduce iron and vitamin A deficiencies in young Amazonian children[J].Public Health Nutr,2016,19(16):3039-3047.
[35] Suchdev PS,Ruth LJ,Woodruff BA,et al.Selling sprinkles micronutrient powder reduces anemia,iron deficiency,and vitamin A deficiency in young children in Western Kenya:a cluster-randomized controlled trial[J].Am J Clin Nutr,2012,95(5):1223-1230.
[36] 李帅,张琨,邱洁,等.婴幼儿辅食营养包对6～24个月龄婴幼儿营养干预的效果评价[J].中国妇幼保健,2017,32(1):58-61.
[37] 李冉,张丽敏,马玉霞,等.营养干预对贫困地区学龄儿童维生素A平近期及远期效果评价[J].现代预防医学,2018,45(7):1194-1198.
[38] Klemm RD,Palmer AC,Greig A,et al.A changing landscape for vitamin a programs:implications for optimal intervention packages,program monitoring,and safety[J].Food Nutr Bull,2016,37(Suppl 2):75-86.

儿童维生素A全球干预进展

Progress on global interventions for vitamin A in children

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	向伟. 儿童青少年脂质异常血症早期预防与成人期心血管健康[J]. 中国儿童保健杂志, 2023, 31(7): 697-702.
[2]	吴婷, 李斐. 生命早期不利因素与慢性疾病的发生与预防[J]. 中国儿童保健杂志, 2023, 31(7): 703-706.
[3]	刘浩东, 李成, 赵敏, 席波. 儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 707-712.
[4]	刘敏, 张倩, 杨亭, 陈洁, 陈立, 代英, 贾飞勇, 武丽杰, 郝燕, 李玲, 张婕, 柯晓燕, 衣明纪, 洪琦, 陈津津, 方拴锋, 王益超, 王琦, 金春华, 李廷玉. 全国多中心学龄前儿童血清叶酸现况调查[J]. 中国儿童保健杂志, 2023, 31(7): 713-717.
[5]	霍言言, 刘钟泠, 马玲, 吴丹, 汪秀莲, 仇晓艳, 窦家莹, 任玉倩, 李亦诚, 洪霞, 陈津津. 真实世界2岁以下儿童不同体型匀称度现况及风险因素[J]. 中国儿童保健杂志, 2023, 31(7): 718-723.
[6]	刘慧娟, 宋志霄, 高南南, 张莉, 孙瑾, 乔秀芸, 柯佳媚, 李燕. 2～6岁儿童词汇和语法发展现状及相关因素分析[J]. 中国儿童保健杂志, 2023, 31(7): 724-730.
[7]	李荣, 李年, 吴丹丹, 黄荣, 陈银花. 盐酸哌甲酯缓释片对注意缺陷多动障碍儿童生长的影响[J]. 中国儿童保健杂志, 2023, 31(7): 731-735.
[8]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[9]	杨钰儒, 王红, 许树红, 曹艳梅, 孟仙, 葛冬梅. 0～14岁儿童骨骼发育与维生素K的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 746-750.
[10]	叶芝旭, 余福勋. 肠道微生物与儿童呼吸道病毒感染的研究进展[J]. 中国儿童保健杂志, 2023, 31(7): 766-769.
[11]	曹慧, 严双琴, 关宏岩. 亲子互动对儿童早期发展结局的影响[J]. 中国儿童保健杂志, 2023, 31(7): 770-774.
[12]	张容, 吴襄仪, 朱一民, 朱文丽, 《儿童肥胖预防与控制指南》修订委员会. 就餐地点与儿童肥胖的定性循证研究[J]. 中国儿童保健杂志, 2023, 31(7): 775-780.
[13]	李玮玮, 张丹丹, 刘晓鸣, 陈娇, 夏露. 探讨基于互联网技术的长程管理模式在难治性癫痫患儿中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 781-784.
[14]	朱丽君, 李彪章, 周嘉雯, 吴柏欣, 李卫东. 1990—2019年中国5岁以下儿童低体重疾病负担分析[J]. 中国儿童保健杂志, 2023, 31(7): 790-793.
[15]	曹亚船, 豆吉娟, 马亚萍, 任金冬, 陈新颜. 肥胖儿童脂质代谢与左心室肥厚及左心室重构的相关性[J]. 中国儿童保健杂志, 2023, 31(7): 809-812.