关键词: 维生素E, 缺乏症, 儿童

Abstract: Objective To investigate the serum levels of vitamin E in healthy children in China,in order to provide basis for dietary guidance. Methods Serum vitamin E levels were measured by reverse phase high performance liquid chromatography(RP-HPLC) with fluorescence detection method.Clinical data of healthy children in the research group of "Study on the correlation between vitamin A and E levels and the development of children′s recurrent respiratory tract infections" were collected and analyzed. Results A total of 41 964 healthy children were included.The average level of vitamin E was(9.12±2.96)mg/L, and serum vitamin E level decreased with the increasing of age(P<0.001) .Vitamin E deficiency and insufficiency rates accounted for 21.49%, of which, the deficiency rate was only 3.36%(1 409/41 964), and the insufficiency rate was 18.13%(7 609/41 964).The vitamin E deficiency and insufficiency rates of children were different in different age groups, which were 4.1% and 13.0% in children under 3 years old and 2.5% and 24.0% in children older than 3 years old, respectively(P<0.001).There was significant difference on the serum level of vitamin E between different regions of China.Children in eastern and central areas whose serum vitamin E levels were in normal range was more than that in western and northeastern areas(P<0.001). Conclusion In general, serum vitamin E level of healthy children in China is in good condition.Vitamin E deficiency and insufficiency accounted for 1/4 of children aged 3 years and over, and further researches are warranted for exploring reasons.

Key words: vitamin E, deficiency, children