维生素D影响新生儿黄疸的可能机制

doi:10.11852/zgetbjzz2020-1341

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (9): 978-980.DOI: 10.11852/zgetbjzz2020-1341

维生素D影响新生儿黄疸的可能机制

黄馨琳, 赵琳

昆明医科大学第二附属医院,云南昆明 650032

收稿日期:2020-07-12 修回日期:2020-10-15 发布日期:2021-09-07 出版日期:2021-09-10
通讯作者: 赵琳,E-mail:13888410901@163.com
作者简介:黄馨琳(1995-),云南人,硕士研究生在读,主要研究方向为儿童营养及新生儿疾病。

Possible mechanisms of vitamin D affecting neonatal jaundice

HUANG Xin-Lin, ZHAO Lin

The Second Affiliated Hospital of Kunming Medical University, Kunming,Yunnan 650032,China

Received:2020-07-12 Revised:2020-10-15 Online:2021-09-10 Published:2021-09-07
Contact: ZHAO Lin,E-mail:13888410901@163.com

摘要/Abstract

摘要： 维生素D是一类重要的脂溶性维生素,不仅可以调节机体的钙磷代谢,还具有抗氧化、抗感染、免疫调节、促进细胞增殖分化等作用。近年来的研究发现不同的血清维生素D水平还与新生儿黄疸有关。基于新生儿黄疸影响因素众多,本文就维生素D影响新生儿黄疸的可能机制进行综述。

关键词: 维生素D, 新生儿黄疸, 氧化应激, 炎症反应

Abstract: Vitamin D is an important liposoluble vitamin, which can not only regulate calcium and phosphorus metabolism, but also have the functions of anti-oxidation, anti-infection, immunomodulation, promoting cell proliferation and differentiation. Recent studies have found that different levels of serum vitamin D are also associated with neonatal jaundice. In view of many influencing factors of neonatal jaundice, this review combs the possible mechanism of vitamin D affecting neonatal jaundice.

Key words: vitamin D, neonatal jaundice, oxidative stress, inflammation

中图分类号:

R722.17

黄馨琳, 赵琳. 维生素D影响新生儿黄疸的可能机制[J]. 中国儿童保健杂志, 2021, 29(9): 978-980.

HUANG Xin-Lin, ZHAO Lin. Possible mechanisms of vitamin D affecting neonatal jaundice[J]. Chinese Journal of Child Health Care, 2021, 29(9): 978-980.

参考文献

[1] Jungert A, Neuhauserberthold M. Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and anti-oxidative status in older adults[J]. Exp Gerontol, 2018, 110: 291-297.
[2] Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: an endocrine society scientific statement[J]. Endocr Rev, 2012, 33(3): 456-492.
[3] Saggese G,Vierucci F,Prodam F,et al.Vitamin D in pediatric age: Consensus of the italian pediatric society and the italian society of preventive and social pediatrics,jointly with the italianfederation of pedia-tricians[J].Italian Journal of Pediatrics,2018,44(1):51-91.
[4] 邵肖梅,叶鸿瑁,岳小汕,等.实用新生儿学[M].5版.北京:人民卫生出版社,2019.
[5] 纪俊敏, 谢文磊. 生物体系中脂质过氧化及抗氧化剂抗氧化活性的检测与评价[J]. 中国油脂, 2004,32(7): 33-37.
[6] Sepidarkish M, Farsi F, Akbari-Fakhrabadi M, et al. The effect of vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials[J]. Pharmacol Res, 2018.DOI:10.1016/j.phrs.2018.11.011.
[7] Chen L, Yang R, Qiao W, et al. 1,25-dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling[J]. Aging Cell, 2019, 18(3):e12951.
[8] Aletayeb SMH, Dehdashtiyan M, Aminzadeh M, et al. Comparison between maternal and neonatal serum vitamin D levels in term jaundiced and nonjaundiced cases[J]. J Chin Med Assoc, 2016, 79(11): 614-617.
[9] Mutlu M, Çayir A,Çayir Y, et al. Vitamin D and hyperbilirubinaemia in neonates[J]. HK J Paediatr(new series), 2013, 18: 77-81.
[10] Abhimanyu, Coussens AK. The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease[J]. Photochemical and Photobiological Sciences, 2017, 16(3): 314-338.
[11] Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune system-working in harmony to reduce the risk of infection[J]. Nutrients,2020,12:236
[12] Abhimanyu, Coussens AK. The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease[J]. Photochem Photobiol Sci,2017,16(3): 314-338.
[13] Hong M, Xiong T, Huang J, et al. Association of vitamin D supplementation with respiratory tract infection in infants[J]. Matern Child Nutr,2020,16(3):e12987.
[14] Grant WB, Lahore H, Mcdonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths[J]. Nutrients, 2020, 12(4): 988.
[15] Hoan NX, Khuyen N, Binh MT, et al. Association of vitamin D deficiency with hepatitis B virus - related liver diseases[J]. BMC Infect Dis,2016, 16(1): 507.
[16] Zhuang P, Sun S, Dong R, et al. Associations between vitamin D and liver function and liver fibrosis in patients with biliary atresia[J]. Gastroenterol Res Pract, 2019, 2019: 4621372.
[17] Abdelrahman N, Sharawy MH, Megahed N, et al. Vitamin D3 abates BDL-induced cholestasis and fibrosis in rats via regulating Hedgehog pathway[J]. Toxicol Appl Pharmacol, 2019, 380: 114697.
[18] Beilfuss A,Sowa JP, Sydor S, et al.Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently[J].Gut,2015,64(5):791-799.
[19] Zhuang P, Sun S, Dong R, et al. Associations between Vitamin D andliver function and liver fibrosis in patients with biliary atresia[J].Gastroenterol Res Pract, 2019, 2019: 4621372.
[20] Tavakoli H, Rostami H, Avan A, et al. High dose vitamin D supplementation is associated with an improvement in serum markers of liver function[J]. Bio Factors, 2019, 45(3): 335-342.
[21] 王少亭, 乐娟, 袁腾飞, 等. 血清25羟基维生素D与新生儿黄疸的关系[J]. 中国现代医学杂志, 2020, 30(9): 65-69.

维生素D影响新生儿黄疸的可能机制

Possible mechanisms of vitamin D affecting neonatal jaundice

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李嘉, 张延赤. 维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 516-520.
[2]	刘金, 张芳, 王建忠. 脑瘫患儿血清25-羟维生素D水平与小腿骨骼肌发育及粗大运动功能量表评分的关系[J]. 中国儿童保健杂志, 2023, 31(5): 541-545.
[3]	叶夕霞, 朱之心, 陈明明, 张雅琴, 周静, 曹文婷. 儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析[J]. 中国儿童保健杂志, 2023, 31(4): 416-421.
[4]	杨柳, 刘玉山, 吴宁渤, 孙静. 青少年抑郁症首发患者血清25-羟基维生素D₃、维生素D结合蛋白水平变化及临床意义[J]. 中国儿童保健杂志, 2023, 31(3): 259-262.
[5]	沈富辉, 尹立琴, 王凡. 高同型半胱氨酸致神经管畸形的研究进展[J]. 中国儿童保健杂志, 2023, 31(2): 176-179.
[6]	蔡冬, 周丽霞, 许花芬. MiR-223-3p通过靶向NLRP3对坏死性小肠结肠炎新生大鼠肠组织的炎症反应和细胞损伤的影响[J]. 中国儿童保健杂志, 2023, 31(1): 46-51.
[7]	蒋雪, 高健, 洪泽, 周文娣. 维生素D治疗肥胖合并非酒精性脂肪肝儿童的临床研究[J]. 中国儿童保健杂志, 2022, 30(9): 970-974.
[8]	宋晓红, 刘影, 施姣, 赵豆豆, 魏君香, 张楠, 王淑慧. 补充钙及维生素D对2～3岁幼儿身长的影响[J]. 中国儿童保健杂志, 2022, 30(9): 1037-1040.
[9]	尤海珍, 周一舫, 谢婧, 金志娟, 王广海, 孙克兴. 维生素D与抽动障碍临床相关性分析[J]. 中国儿童保健杂志, 2022, 30(8): 904-907.
[10]	房海波, 王荣, 褚琳娜, 冯艳芳, 白容荣, 郭丰桐. 血清维生素D水平与伴中央颞区棘波的儿童良性癫痫共患注意缺陷多动障碍患儿认知功能的相关性分析[J]. 中国儿童保健杂志, 2022, 30(7): 775-778.
[11]	游芳, 孔庆平, 强光峰, 赵静, 任雪云. 维生素D水平与极低出生体重儿临床结局的相关性研究[J]. 中国儿童保健杂志, 2022, 30(2): 216-220.
[12]	何青, 徐磊, 谢江. 类固醇激素与孤独症谱系障碍的相关性研究进展[J]. 中国儿童保健杂志, 2022, 30(11): 1221-1225.
[13]	张旭东, 刘洋. 母体维生素D营养状态与子代食物过敏相关性研究进展[J]. 中国儿童保健杂志, 2022, 30(10): 1108-1111.
[14]	杨晓燕, 侯成, 衣明纪. 维生素D在儿童抽动障碍中的神经生化与免疫机制研究进展[J]. 中国儿童保健杂志, 2021, 29(8): 857-860.
[15]	韩旭, 王书举, 谷华丽. 细胞间黏附因子水平与儿童哮喘严重程度及气道炎症反应的相关性分析[J]. 中国儿童保健杂志, 2021, 29(8): 898-901.