维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展

doi:10.11852/zgetbjzz2022-1081

摘要/Abstract

摘要： 维生素D及其受体在人体不同区域有广泛表达,后者介导活性维生素D的所有分子功能,其基因多态性已被证实与多种发育障碍类疾病易感性相关。现对维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进行综述,以期为患儿临床早期预防、干预和治疗提供理论参考。

关键词: 维生素D, 维生素D受体, 基因多态性, 神经发育障碍

Abstract: Vitamin D and its receptors (VDR) are widely expressed in various regions of human body.VDR mediates all molecular effects of active vitamin D, and its gene polymorphisms have been linked to a variety of neurodevelopmental disease.This article reviews the association of vitamin D and VDR gene polymorphisms with childhood neurodevelopmental disorders, providing theoretical reference for early prevention, intervention and treatment in children.

Key words: vitamin D, vitamin D receptor, gene polymorphisms, neurodevelopmental disorders

中图分类号:

R749.94

李嘉, 张延赤. 维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 516-520.

LI Jia, ZHANG Yanchi. Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children[J]. Chinese Journal of Child Health Care, 2023, 31(5): 516-520.

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