关键词: 辅助生殖技术, 试管婴儿, 足月儿, 神经心理发育

Abstract: Objective To compare the physical development and neuropsychological development level of test-tube full-term infants by assisted reproductive technology (ART) with that of naturally conceived (NC) healthy infants, so as to provide a scientific basis for the early comprehensive development of test-tube infants. Methods Totally 60 ART term infants and 60 NC term infants were enrolled and their relevant information was collected in this study from January 1st, 2019 to December 31st, 2020.Infants′ health check-up data were followed up at 6 and 12 months old.The Children′s Neuropsychological Behavioral Development Assessment (2016 version) was used to assess the neuropsychological behavioral development of infants. Results There were significant differences on parental age, the incidence of pregnancy complications and cesarean section and multiple fetus rate between ART infants and NC term infants(t=11.141, 15.392, χ²=23.008, 28.104,36.936,P<0.001), but the differences in the length and weight at birth and incidence of birth complications between the two groupswere not significant (P>0.05).ART term infants and NC term infants had the consistent trends on physical development levels at 6 months old and 12 months old (P>0.05).At 6 months old, the scores of fine motor development, language development and total development quotient of ART infants were significantly lower than those of NC infants (t=6.455,4.583,6.895,P＜0.05), but the neuropsychological and behavioral development levels of the two groups were similar at 12 months old (P>0.05). Conclusions Although assisted reproduction full-term test-tube infants face adverse high-risk factors during the fetal period, the physical development at birth and infancy reaches the level of naturally conceived infants.The early development of fine motor and language skills of ART infants is lower than that of naturally conceived infants, but they can catch up with the level of naturally conceived babies at the age of 12 months old, indicating the importance of promoting the early comprehensive development of ART infants.

Key words: assisted reproduction technology, test-tube infant, full-term infant, neuropsychological development