孤独症谱系障碍儿童睡眠问题及其与褪黑素相关性研究进展

doi:10.11852/zgetbjzz2021-0215

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (6): 651-654.DOI: 10.11852/zgetbjzz2021-0215

所属专题：儿童睡眠；孤独症谱系障碍

孤独症谱系障碍儿童睡眠问题及其与褪黑素相关性研究进展

王瀞萩, 王成举综述, 胡斌审校

陆军军医大学第二附属医院儿科,重庆 400037

收稿日期:2021-02-09 修回日期:2021-03-22 发布日期:2022-06-28 出版日期:2022-06-10
通讯作者: 胡斌,E-mail58127652@qq.com
作者简介:王瀞萩(1991-),女,重庆人,技师,本科学历,主要研究方向为神经发育障碍性疾病与发育行为。

Research advances on the relationship between melatonin and sleep problems in children with autism spectrum disorder

WANG Jing-qiu, WANG Cheng-ju, HU Bin

Department of Pediatrics,the Second Affiliated Hospital of Army Medical University,Chongqing 400037,China

Received:2021-02-09 Revised:2021-03-22 Online:2022-06-10 Published:2022-06-28
Contact: HU Bin,E-mail: 58127652@qq.com

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是一组神经发育障碍性疾病,常伴有的昼夜节律失常和睡眠问题,睡眠问题不仅可能加重ASD儿童的某些核心症状,还可能影响康复训练效果。ASD儿童睡眠问题的临床表现形式多样,但确切机制尚不明确,研究发现其与褪黑素分泌代谢异常密切相关,且褪黑素治疗有效、安全。本文主要对ASD儿童睡眠问题及其与褪黑素相关研究进展作一综述,旨在为改善ASD儿童睡眠问题以及制定有效的干预方案提供依据。

关键词: 孤独症谱系障碍, 睡眠问题, 褪黑素, 儿童

Abstract: Autism spectrum disorder(ASD) is a group of neurodevelopmental disorders,often accompanied by circadian rhythm disorders and sleep problems. Sleep problems may not only aggravate some of the core symptoms of ASD children,but also affect the effect of rehabilitation training. The clinical manifestations of sleep problems in ASD children are various,but the exact mechanism is not clear. Studies have found that it is closely related to abnormal melatonin secretion and metabolism,and melatonin treatment is effective and safe. This paper mainly reviews the sleep problems of ASD children and the research progress related to melatonin in order to provide basis for improving sleep quality of ASD children and formulating effective intervention programs.

Key words: autism spectrum disorder, sleep problem, melatonin, children

中图分类号:

R749.94

王瀞萩, 王成举, 胡斌. 孤独症谱系障碍儿童睡眠问题及其与褪黑素相关性研究进展[J]. 中国儿童保健杂志, 2022, 30(6): 651-654.

WANG Jing-qiu, WANG Cheng-ju, HU Bin. Research advances on the relationship between melatonin and sleep problems in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2022, 30(6): 651-654.

参考文献

[1] Wu ZY,Huang SD,Zou JJ,et al.Autism spectrum disorder(ASD):disturbance of the melatonin system and its implications[J].Biomed Pharmacother,2020,130: 110496.
[2] 刘贤,林穗芳,陈文雄,等. 中国儿童孤独症谱系障碍患病率Meta分析[J].中国儿童保健杂志,2018,26(4):402-406.
[3] Klein N,Kemper KJ. Integrative approaches to caring for children with autism[J].Curr Probl Pediatr Adolesc Health Care,2016,46(6):195-201.
[4] Goldman SE,Alder ML,Burgess HJ,et al.Characterizing sleep in adolescents and adults with autism spectrum disorders[J].J Autism Dev Disord,2017,47(6):1682-1695.
[5] Dmitrzak-Weglarz M,Reszka E. Pathophysiology of depression: molecular regulation of melatonin homeostasis—current status[J].Neuropsychobiology,2017,76(3):117-129.
[6] Maitra S,Bhattacharya D,Das S,et al.Melatonin and its anti-glioma functions:A comprehensive review[J].Rev Neurosci,2019,30(5),527-541.
[7] Rana M,Kothare S,DeBassio W. The assessment and treatment of sleep abnormalities in children and adolescents with autism spectrum disorder:A review[J].J Can Acad Child Adolesc Psychiatry,2021,30(1):25-35.
[8] Murata E,Mohri I,Kato-Nishimura K,et al.Evaluation of behavioral change after adenotonsillectomy for obstructive sleep apnea in children with autism spectrum disorder[J].Res Dev Disabil,2017,65:127-139.
[9] Kanney ML,Durmer JS,Trotti LM,et al.Rethinking bedtime resistance in children with autism:Is restless legs syndrome to blame?[J].J Clin Sleep Med,2020,16(12):2029-2035.
[10] Reynolds AM,Soke GN,Sabourin KR,et al.Sleep problems in 2- to 5-year-olds with autism spectrum disorder and other developmental delays[J].Pediatrics,2019,143(3):e20180492.
[11] Kamara D,Beauchaine TP. A review of sleep disturbances among infants and children with neurodevelopmental disorders[J].Rev J Autism Dev Disord,2020,7(3):278-294.
[12] Köse S,Y¹lmaz H,Ocakoglu FT,et al.Sleep problems in children with autism spectrum disorder and intellectual disability without autism spectrum disorder[J].Sleep Med,2017,40:69-77.
[13] Sivertsen B,Posserud MB,Gillberg C,et al.Sleep problems in children with autism spectrum problems: A longitudinal population-based study[J].Autism,2012,16(2):139-150.
[14] 韩盼盼,邹明扬,杨晓蕾,等. 孤独症谱系障碍患儿睡眠问题及其与6-羟基硫酸褪黑素水平的关联性[J].中华儿科杂志,2017,55(12):911-915.
[15] Rzepka-Migut B,Paprocka J. Efficacy and safety of melatonin treatment in children with autism spectrum disorder and attention-deficit/hyperactivity disorder-a review of the literature[J].Brain Sci,2020,10(4):219.
[16] Abdulamir HA,Abdul-Rasheed OF,Abdulghani EA. Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children[J].Saudi Med J,2016,37(1):29-36.
[17] Maruani A,Dumas G,Beggiato A,et al.Morning plasma melatonin differences in autism: beyond the impact of pineal gland volume[J].Front Psychiatry,2019,10:11.
[18] Pagan C,Delorme R,Callebert J,et al.The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders[J].Transl Psychiatry,2014,4(11):e479.
[19] Braam W,Ehrhart F,Maas APHM,et al.Low maternal melatonin level increases autism spectrum disorder risk in children[J].Res Dev Disabil,2018,82:79-89.
[20] Liang Y,Xiao Z,Ke X,et al.Urinary metabonomic profiling discriminates between children with autism and their healthy siblings[J].Med Sci Monit,2020,26:e926634.
[21] Botbol M,Cabon P,Kermarrec S,et al.Biological and psychological rhythms:An integrative approach to rhythms disturbances in autistic disorder[J].J Physiol Paris,2013,107(4):298-309.
[22] 赵琴,邵智. 孤独症谱系障碍儿童睡眠障碍发生机制和治疗的研究进展[J].中国儿童保健杂志,2020,28(1):52-56.
[23] Yuge K,Nagamitsu S,Ishikawa Y,et al.Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders[J].BMC Psychiatry,2020,20(1):445.
[24] Bruni O,Alonso-Alconada D,Besag F,et al.Current role of melatonin in pediatric neurology:Clinical recommendations[J].Eur J Paediatr Neurol,2015,19(2):122-133.
[25] Cortesi F,Giannotti F,Sebastiani T,et al.Controlled-release melatonin,singly and combined with cognitive behavioral therapy,for persistent insomnia in children with autism spectrum disorders:A randomized placebo-controlled trial[J].J Sleep Res,2012,21(6):700-709.
[26] Gringras P,Nir T,Breddy J,et al.Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder[J].J Am Acad Child Adolesc Psychiatry,2017,56(11):948-957.
[27] Schroder CM,Malow BA,Maras A,et al.Pediatric prolonged-release melatonin for sleep in children with autism spectrum disorder: impact on child behavior and caregiver's quality of life[J].J Autism Dev Disord,2019,49(8):3218-3230.
[28] Andersen IM,Kaczmarska J,McGrew SG,et al.Melatonin for insomnia in children with spectrum disorders[J].J Child Neurol,2008,23(5):482-485.
[29] Cuomo BM,Vaz S,Lee EAL,et al.Effectiveness of sleep-based interventions for children with autism spectrum disorder:A Meta-synthesis[J].Pharmacotherapy,2017,37(5):555-578.
[30] Malow BA,Findling RL,Schroder CM,et al.Sleep,growth,and puberty after two years of prolonged-release melatonin in children with autism spectrum disorder[J].J Am Acad Child Adolesc Psychiatry,2021,60(2):252-261.
[31] Maras A,Schroder CM,Malow BA,et al.Long-term efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder[J].J Child Adolesc Psychopharmacol,2018,28(10):699-710.
[32] Van Geijlswijk IM,Mol RH,Egberts TC,et al.Evaluation of sleep,puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia[J].Psychopharmacology,2011,216(1):111-120.
[33] Carr R,Wasdell MB,Hamilton D,et al.Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders[J].J Pineal Res,2007,43(4):351-359.
[34] Howes OD,Rogdaki M,Findon JL,et al.Autism spectrum disorder:Consensus guidelines on assessment,treatment and research from the British association for psychopharmacology[J].J Psychopharmacol,2018,32(1):3-29.

孤独症谱系障碍儿童睡眠问题及其与褪黑素相关性研究进展

Research advances on the relationship between melatonin and sleep problems in children with autism spectrum disorder

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	向伟. 儿童青少年脂质异常血症早期预防与成人期心血管健康[J]. 中国儿童保健杂志, 2023, 31(7): 697-702.
[2]	吴婷, 李斐. 生命早期不利因素与慢性疾病的发生与预防[J]. 中国儿童保健杂志, 2023, 31(7): 703-706.
[3]	刘浩东, 李成, 赵敏, 席波. 儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 707-712.
[4]	刘敏, 张倩, 杨亭, 陈洁, 陈立, 代英, 贾飞勇, 武丽杰, 郝燕, 李玲, 张婕, 柯晓燕, 衣明纪, 洪琦, 陈津津, 方拴锋, 王益超, 王琦, 金春华, 李廷玉. 全国多中心学龄前儿童血清叶酸现况调查[J]. 中国儿童保健杂志, 2023, 31(7): 713-717.
[5]	霍言言, 刘钟泠, 马玲, 吴丹, 汪秀莲, 仇晓艳, 窦家莹, 任玉倩, 李亦诚, 洪霞, 陈津津. 真实世界2岁以下儿童不同体型匀称度现况及风险因素[J]. 中国儿童保健杂志, 2023, 31(7): 718-723.
[6]	刘慧娟, 宋志霄, 高南南, 张莉, 孙瑾, 乔秀芸, 柯佳媚, 李燕. 2～6岁儿童词汇和语法发展现状及相关因素分析[J]. 中国儿童保健杂志, 2023, 31(7): 724-730.
[7]	李荣, 李年, 吴丹丹, 黄荣, 陈银花. 盐酸哌甲酯缓释片对注意缺陷多动障碍儿童生长的影响[J]. 中国儿童保健杂志, 2023, 31(7): 731-735.
[8]	张超. 早期介入丹佛模式在不同病情程度孤独症谱系障碍儿童康复中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 736-740.
[9]	杨钰儒, 王红, 许树红, 曹艳梅, 孟仙, 葛冬梅. 0～14岁儿童骨骼发育与维生素K的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 746-750.
[10]	叶芝旭, 余福勋. 肠道微生物与儿童呼吸道病毒感染的研究进展[J]. 中国儿童保健杂志, 2023, 31(7): 766-769.
[11]	曹慧, 严双琴, 关宏岩. 亲子互动对儿童早期发展结局的影响[J]. 中国儿童保健杂志, 2023, 31(7): 770-774.
[12]	张容, 吴襄仪, 朱一民, 朱文丽, 《儿童肥胖预防与控制指南》修订委员会. 就餐地点与儿童肥胖的定性循证研究[J]. 中国儿童保健杂志, 2023, 31(7): 775-780.
[13]	李玮玮, 张丹丹, 刘晓鸣, 陈娇, 夏露. 探讨基于互联网技术的长程管理模式在难治性癫痫患儿中的应用研究[J]. 中国儿童保健杂志, 2023, 31(7): 781-784.
[14]	朱丽君, 李彪章, 周嘉雯, 吴柏欣, 李卫东. 1990—2019年中国5岁以下儿童低体重疾病负担分析[J]. 中国儿童保健杂志, 2023, 31(7): 790-793.
[15]	曹亚船, 豆吉娟, 马亚萍, 任金冬, 陈新颜. 肥胖儿童脂质代谢与左心室肥厚及左心室重构的相关性[J]. 中国儿童保健杂志, 2023, 31(7): 809-812.