关键词: 瘦素, 基因多态性, 单纯性肥胖, 学龄前儿童, 壮族

Abstract: Objective To explore the relationship of leptin receptor (LEPR) gene rs1137100 sites single nucleotide polymorphisms (SNPs) with simple obesity. Methods 200 preschool children in Liuzhou were enrolled.Body height,weight and waistline were measured,LEPR gene rs1137100 (A/G) sites single nucleotide polymorphisms were detected by SNaPshot assay. Results The AA,AG and GG genotype frequencies of LEPR gene rs1137100(A/G) in simple obesity group and normal control group were 66.4%,29.9%,3.7% and 68.3%,27.7%,4.0%,respectively,the A,G allelic frequencies in simple obesity group and normal control group were 81.3%,18.7% and 82.2%,17.8%,respectively.And OR was 1.06,95%CI was 0.64~1.74.The genotype and allelic frequencies of rs1137100 (A/G) in simple obesity children were not significantly different from those in controls (P>0.05),the LEPR gene rs1137100 (A/G) sites single nucleotide polymorphisms were found in Hardy Weinberg equilibrium. Conclusions LEPR gene rs1137100 polymorphisms are not associated with simple obesity in Chinese Zhuang preschool children in Liuzhou of Guangxi province.

Key words: leptin, genetic polymorphism, simple obesity, preschool children, Zhuang nationality