肠道微生物干预在孤独症谱系障碍中的应用展望

doi:10.11852/zgetbjzz2021-1702

中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (3): 279-283.DOI: 10.11852/zgetbjzz2021-1702

肠道微生物干预在孤独症谱系障碍中的应用展望

赵英欣^1,2, 何凡^1,2, 郑毅^1,2

1.首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京 100088;
2.首都医科大学人脑保护高精尖创新中心,北京 100069

收稿日期:2021-11-16 修回日期:2022-03-15 发布日期:2023-02-28 出版日期:2023-03-01
通讯作者: 郑毅,E-mail:yizheng@ccmu.edu.cn
作者简介:赵英欣(1981-),女,河北人,主治医师,博士在读,主要研究方向为儿童少年精神医学。
基金资助:
北京市医院管理局儿科学科协同发展中心专项经费资助(XTYB201812);北京市医院管理中心临床医学发展专项经费资助(ZYLX202128)

Application of gut microbiom intervention in autism spectrum disorder

ZHAO Yingxin^1,2, HE Fan^1,2, ZHENG Yi^1,2

1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China

Received:2021-11-16 Revised:2022-03-15 Online:2023-03-01 Published:2023-02-28
Contact: ZHENG Yi, E-mail: yizheng@ccmu.edu.cn

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)患病率不断攀升,已成为现代医学面临的主要挑战之一。除了社交互动的持续损害和局限的、重复的兴趣、活动或行为模式这些核心症状之外,还会伴随如胃肠道症状、易怒和攻击行为、情绪问题、多动症状、睡眠问题等,给照料者带来沉重精神和经济负担。目前ASD病因尚不明确,治疗主要以行为改善为主,尚无有效药物可以治疗其核心症状。近年来,肠道微生物作为ASD患者危险因素的潜在中介作用受到越来越多的关注。临床研究表明:改变肠道微生物生态环境失调不仅可改善ASD的胃肠症状,还可改善其适应不良行为。未来需要更多的研究探索肠道微生物对ASD症状的影响,以期为临床提供更多有力的证据。

关键词: 孤独症谱系障碍, 肠道微生物, 益生菌, 益生元, 粪菌移植

Abstract: The prevalence of autism spectrum disorder(ASD) is rising, which has become one of the main challenges of modern medicine. In addition to the core symptoms such as continuous damage to social interaction and limited and repeated interests, activities or behavior patterns, it will also be accompanied by gastrointestinal symptoms, irritability and aggressive behavior, emotional problems, hyperactivity symptoms, sleep problems, etc., which will bring heavy mental and economic burden to caregivers. At present, the etiology of ASD is not clear.The main treatment of ASD is behavioral therapy, and there is no effective drug to treat its core symptoms. In recent years, more and more attention has been paid to the potential mediating role of gut microbiom as risk factors in patients with ASD. Several clinical studies have shown that changes of gut microbiom can not only improve the gastrointestinal symptoms of ASD, but also improve its maladaptive behavior. Further studies are warranted to explore the effect of gut microbiom on ASD symptoms so as to provide more powerful evidence for clinical practice.

Key words: autism, gut microbiom, probiotics, probiotics, fecal microbiota transplant

中图分类号:

R749.94

赵英欣, 何凡, 郑毅. 肠道微生物干预在孤独症谱系障碍中的应用展望[J]. 中国儿童保健杂志, 2023, 31(3): 279-283.

ZHAO Yingxin, HE Fan, ZHENG Yi. Application of gut microbiom intervention in autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2023, 31(3): 279-283.

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肠道微生物干预在孤独症谱系障碍中的应用展望

Application of gut microbiom intervention in autism spectrum disorder

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