妊娠期睡眠剥夺对子代的影响

doi:10.11852/zgetbjzz2022-1367

中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (5): 512-515.DOI: 10.11852/zgetbjzz2022-1367

妊娠期睡眠剥夺对子代的影响

金青青, 吕靖, 周节, 肖静, 方伟, 罗向红

湖北医药学院附属十堰市太和医院麻醉科,湖北十堰 442000

收稿日期:2022-11-14 修回日期:2023-01-05 发布日期:2023-05-06 出版日期:2023-05-10
通讯作者: 罗向红,E-mail:95luoxianghong@163.com
作者简介:金青青(1995-),女,湖北人,硕士研究生在读,主要研究方向为麻醉药对小儿神经发育的影响。
基金资助:
湖北省科技厅省自然科学基金-青年项目(2020CFB335);湖北省教育厅科技项目-中青年人才项目(Q20212104)

Effects of sleep deprivation during pregnancy on the offspring

JIN Qingqing, LYU Jing, ZHOU Jie, XIAO Jing, FANG Wei, LUO Xianghong

Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000,China

Received:2022-11-14 Revised:2023-01-05 Online:2023-05-10 Published:2023-05-06
Contact: LUO Xianghong, E-mail:95luoxianghong@163.com

摘要/Abstract

摘要： 睡眠剥夺是指由于各种原因引起的机体睡眠时间不足的状态。越来越多的证据表明,与未孕女性相比,妊娠期处于特殊生理时期,容易发生不同程度的睡眠剥夺,并且可能对子代产生严重的不良后果。本文总结了妊娠期睡眠剥夺对子代的影响并予以综述,或可对促进孕期保健和改善后代结局提供一些临床思路。

关键词: 妊娠期, 睡眠剥夺, 子代, 不良影响

Abstract: Sleep deprivation is a state in which the body does not get enough sleep due to various reasons.There is growing evidence that pregnancy is a special physiological period when sleep deprivation is more likely to occur to varying degrees than in non-pregnant women, and that it may have serious adverse consequences for the offspring.This article summarizes and reviews the effects of sleep deprivation during pregnancy on the offspring and may provide some clinical ideas to promote maternal health and improve offspring outcomes.

Key words: pregnancy, sleep deprivation, offspring, adverse effects

中图分类号:

R714.2

金青青, 吕靖, 周节, 肖静, 方伟, 罗向红. 妊娠期睡眠剥夺对子代的影响[J]. 中国儿童保健杂志, 2023, 31(5): 512-515.

JIN Qingqing, LYU Jing, ZHOU Jie, XIAO Jing, FANG Wei, LUO Xianghong. Effects of sleep deprivation during pregnancy on the offspring[J]. Chinese Journal of Child Health Care, 2023, 31(5): 512-515.

参考文献

[1] Rault C, Sangaré A, Diaz V, et al.Impact of sleep deprivation on respiratory motor output and endurance: A physiological study[J].Am J Resp Crit Care, 2020,201(8):976-983.
[2] Sedov ID, Anderson NJ, Dhillon AK, et al.Insomnia symptoms during pregnancy: A Meta-analysis[J].J Sleep Res, 2021,30(1):e13207.
[3] 张楚珺, 粟义佳, 陈焱, 等.妊娠期睡眠质量调查及睡眠疾病相关因素分析:一项多中心横断面临床研究[J].中华耳鼻咽喉头颈外科杂志, 2022,57(03):308-316.
Zhang CJ, Su YJ, Chen Y, et al.Sleep quality and sleep disturbances in Chinese pregnant women: A multicenter crosssectional study[J].Chin J Otorhinolaryngol Head Neck Surg, 2022,57(3):308-316.(in Chinese)
[4] Robertson NT, Turner JM, Kumar S.Pathophysiological changes associated with sleep disordered breathing and supine sleep position in pregnancy[J].Sleep Med Rev, 2019,46:1-8.
[5] 唐静, 卢琼芳, 丘驰, 等.孕妇睡眠质量的研究进展[J].现代临床医学, 2021,47(4):275-278.
Tang J, Lu QF, Qiu C.et al.Advances in the study of maternal sleep quality[J].J Mod Clin Med,2021,47(4):275-278.(in Chinese)
[6] Facco FL, Chan M, Patel SR.Common sleep disorders in pregnancy[J].Obstet Gynecol, 2022,140(2):321-339.
[7] Cai Y, Zheng X, Shen Z, et al.Study on the sleep quality of women pregnant with a second child and the influencing factors[J].Eur J Med Res, 2022,27(1):207.
[8] Yang J, Lin R, Sun K, et al.Incidence and correlates of insomnia and its impact on health-related quality of life among Chinese pregnant women: A cross-sectional study[J].J Reprod Infant Psychol, 2022:1-12.doi:10.1080/02646838.2021.2020228.
[9] Pires GN, Benedetto L, Cortese R, et al.Effects of sleep modulation during pregnancy in the mother and offspring: Evidences from preclinical research[J].J Sleep Res, 2021,30(3):e13135.
[10] Zhao Q, Peng C, Wu X, et al.Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats[J].Neurobiol Dis, 2014,68:57-65.
[11] Zhao Q, Xie X, Fan Y, et al.Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment[J].Sci Rep, 2015,5(1):9513.
[12] Peng Y, Wang W, Tan T, et al.Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats[J].Mol Brain, 2016,9(1):17.
[13] Han Y, Wang J, Zhao Q, et al.Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis[J].Brain Behav Immun, 2020,87:568-578.
[14] Yang W, Zhou X, Zimmermann HR, et al.Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation[J].Mol Psychiatry, 2021,26(6):1880-1897.
[15] Yu Y, Huang Z, Dai C, et al.Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats[J].Neuropharmacology, 2018,133:155-162.
[16] Baratta AM, Buck SA, Buchla AD, et al.Sex differences in hippocampal memory and kynurenic acid formation following acute sleep deprivation in rats[J].Sci Rep, 2018,8(1):6963.
[17] Baratta AM, Kanyuch NR, Cole CA, et al.Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid[J].Neurobiol Stress, 2020,12:100204.
[18] Grech A, Collins CE, Holmes A, et al.Maternal exposures and the infant gut microbiome: A systematic review with meta-analysis[J].Gut Microbes, 2021,13(1):1-30.
[19] Nuriel-Ohayon M, Neuman H, Ziv O, et al.Progesterone increases bifidobacterium relative abundance during late pregnancy[J].Cell Rep, 2019,27(3):730-736.
[20] Yao Z, Li X, Zuo L, et al.Maternal sleep deprivation induces gut microbial dysbiosis and neuroinflammation in offspring rats[J].Zool Res, 2022,43(3):380-390.
[21] Soltis J.The signal functions of early infant crying[J].Behav Brain Sci, 2004,27(4):443-458, 459-490.
[22] Scattoni ML, Crawley J, Ricceri L.Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders[J].Neurosci Biobehav Rev, 2009,33(4):508-515.
[23] Gulia KK, Patel N, Radhakrishnan A, et al.Reduction in ultrasonic vocalizations in pups born to rapid eye movement sleep restricted mothers in rat model[J].PLoS One, 2014,9(1):e84948.
[24] Zhang Y, Cheng Y, Wang Y, et al.Environmental enrichment reverses maternal sleep deprivation-induced anxiety-like behavior and cognitive impairment in CD-1 mice[J].Front Behav Neurosci, 2022,16:943900.
[25] Ahmad SF, Buckley AW, Glaze DG.Neurology of sleep[J].Neurol Clin, 2021,39(3):867-882.
[26] Lyu J, Ye X, Chen Y, et al.Children’s sleep may depend on maternal sleep duration during pregnancy: A retrospective study[J].Nat Sci Sleep, 2020,12:197-207.
[27] Nakahara K, Michikawa T, Morokuma S, et al.Association of maternal sleep before and during pregnancy with sleep and developmental problems in 1-year-old infants[J].Sci Rep, 2021,11(1):11834.
[28] Lin X, Zhai R, Mo J, et al.How do maternal emotion and sleep conditions affect infant sleep: A prospective cohort study[J].BMC Pregnancy Childbirth, 2022,22(1):237.
[29] Aswathy BS, Kumar VM, Gulia KK.Immature sleep pattern in newborn rats when dams encountered sleep restriction during pregnancy[J].Int J Dev Neurosci, 2018,69(1):60-67.
[30] Lo Martire V, Caruso D, Palagini L, et al.Stress & sleep: A relationship lasting a lifetime[J].Neurosci Biobehav Rev, 2020,117:65-77.
[31] Pepin JL, Borel AL, Tamisier R, et al.Hypertension and sleep: Overview of a tight relationship[J].Sleep Med Rev, 2014,18(6):509-519.
[32] Thomal JT, Palma BD, Ponzio BF, et al.Sleep restriction during pregnancy: Hypertension and renal abnormalities in young offspring rats[J].Sleep, 2010,33(10):1357-1362.
[33] Lima ILB, Rodrigues AFAC, Bergamaschi CT, et al.Chronic sleep restriction during pregnancy - repercussion on cardiovascular and renal functioning of male offspring[J].PLoS One, 2014,9(11):e113075.
[34] Argeri R, Nishi EE, Volpini RA, et al.Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring[J].Physiol Rep, 2016,4(16):e12888.
[35] Meng M, Jiang Y, Lin J, et al.The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: A prospective cohort study[J].Clin Epigenetics, 2022,14(1):66.
[36] Harskamp-van Ginkel MW, Ierodiakonou D, Margetaki K, et al.Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure[J].Sleep, 2020,43(12):zsaa110.
[37] Khalyfa A, Carreras A, Almendros I, et al.Sex dimorphism in late gestational sleep fragmentation and metabolic dysfunction in offspring mice[J].Sleep, 2015,38(4):545-557.
[38] Diep Nguyen T.Adiponectin: Role in physiology and pathophysiology[J].Int J Prev Med, 2020,11(1):136.

妊娠期睡眠剥夺对子代的影响

Effects of sleep deprivation during pregnancy on the offspring

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	许钦雯, 徐旭娟, 俞洁, 茅欣欣. 孕期宫内血糖暴露对子代器官功能发育的影响[J]. 中国儿童保健杂志, 2022, 30(9): 985-988.
[2]	钟志鸿, 罗巧燕, 石碧君, 魏坚伟, 钟鑫琪, 崔其亮. 不同类型妊娠期高血压疾病对子代出生状况的影响[J]. 中国儿童保健杂志, 2022, 30(6): 673-676.
[3]	倪松平, 华孝真, 张素春. 2型糖尿病和妊娠期糖尿病对新生儿呼吸窘迫综合征的影响[J]. 中国儿童保健杂志, 2022, 30(4): 450-453.
[4]	李占魁, 白瑞苗. 妊娠期高血糖暴露对子代神经发育结局的影响[J]. 中国儿童保健杂志, 2022, 30(10): 1045-1048.
[5]	贾朝霞, 赵永鲜, 黄丽丽, 王军华, 王朝, 武明辉. 妊娠期糖尿病与儿童超重肥胖的相关性研究[J]. 中国儿童保健杂志, 2021, 29(7): 717-720.
[6]	杨云, 张士发. 糖尿病母亲新生儿大于胎龄儿的危险因素及近期结局[J]. 中国儿童保健杂志, 2021, 29(10): 1125-1129.
[7]	侯杉杉, 杨洁. 妊娠期糖尿病母亲子代0~36月龄生长发育情况研究[J]. 中国儿童保健杂志, 2019, 27(7): 775-778.
[8]	肖平娟, 邵庆亮. 妊娠期糖尿病对子代肺成熟度影响的代谢组学研究进展[J]. 中国儿童保健杂志, 2019, 27(6): 617-619.
[9]	姜春花, 肖丽萍, 黄俊, 李云, 张莺, 钟平莉, 杨红, 苏怡, 骆丹丹. 运用倾向性评分匹配法探讨辅助生殖技术对子代1岁内PDMS评估结果的影响[J]. 中国儿童保健杂志, 2019, 27(5): 495-498.
[10]	宗璐, 吕晔, 张小雪, 张莉, 帖迎春. 宫内注射内毒素对早产子代大鼠学习记忆能力影响的研究[J]. 中国儿童保健杂志, 2019, 27(5): 503-506.
[11]	李晶, 陈宇, 沈畏文, 刘惠娟, 杨佩文. 卵胞浆内单精子注射子代与自然妊娠儿童学龄前期行为发育比较分析[J]. 中国儿童保健杂志, 2018, 26(5): 475-478.
[12]	朱丽霞, 王广海, 姜艳蕊, 林青敏, 邓玉娇, 江帆. 孕晚期母亲睡眠与子代2岁胰岛素和胰岛素抵抗的相关性研究[J]. 中国儿童保健杂志, 2018, 26(5): 488-491.
[13]	姜春花, 肖丽萍, 黄俊, 李云, 杨红, 曹佳燕, 张莺, 钟平莉, 程紊, 张越. 运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响[J]. 中国儿童保健杂志, 2018, 26(10): 1068-1071.
[14]	霍亭竹, 罗小丽, 毛萌. 妊娠期糖尿病对子代健康的影响:代谢综合征的传递[J]. 中国儿童保健杂志, 2017, 25(7): 687-691.
[15]	郑军,王晓鹏. 妊娠期高血压对胎儿及新生儿的影响[J]. 中国儿童保健杂志, 2017, 25(11): 1086-1089.