运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响

doi:10.11852/zgetbjzz2018-26-10-07

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (10): 1068-1071.DOI: 10.11852/zgetbjzz2018-26-10-07

运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响

姜春花¹, 肖丽萍¹, 黄俊¹, 李云¹, 杨红², 曹佳燕², 张莺¹, 钟平莉¹, 程紊¹, 张越¹

1 上海市闵行区妇幼保健院,上海 201102;
2 复旦大学附属儿科医院,上海 201102

收稿日期:2017-12-31 发布日期:2018-10-10 出版日期:2018-10-10
通讯作者: 杨红,E-mail:hyang@shmu.edu.cn
作者简介:姜春花(1983-),女,福建人,医师,硕士研究生,主要从事公共卫生和儿童保健工作。
基金资助:
上海市闵行区科委基金支持(2015MHZ015)

Impact of the assisted reproductive technology on the offsprings′ general movement assessment
by applying propensity score matching

JIANG Chun-hua¹, XIAO Li-ping¹, HUANG Jun¹, LI Yun¹, YANG Hong², CAO Jia-yan², ZHANG Ying¹, ZHONG Ping-li¹, CHENG Wen¹, ZHANG Yue¹

1 Shanghai Minhang Maternal and Child Health Care Hospital,Shanghai 201102,China;
2 Children Hospital of Fudan University,Shanghai 201102,China

Received:2017-12-31 Online:2018-10-10 Published:2018-10-10
Contact: YANG Hong,E-mail:hyang@shmu.edu.cn

摘要/Abstract

摘要： 目的运用倾向性评分匹配(PSM)法探讨辅助生殖技术(ART)对子代全身运动评估(GMs)结果的影响,为ART的远期效果提供参考依据。方法 2015年7月—2017年10月收集在闵行区至少有一次GMs评估且采集信息完整者为研究对象。运用PSM对GMs “早产/扭动”和 “不安运动”两阶段首次结果分别设置匹配容差为0.000 03和0.000 15进行1∶1匹配,分组为ART受孕组和自然受孕组,匹配变量为“性别、出生体重、孕周、胎数,出生抢救史、黄疸、神经疾病和其它疾病史,父母亲的年龄、文化、职业,母亲孕期保胎、服药、糖尿病、高血压和其它疾病史”,比较匹配前后组间差异。结果匹配前,在GMs两阶段ART受孕组结果异常率高于自然受孕组,差异均有统计学意义(χ²＝77.74和15.38,P＜0.01);匹配后,“早产/扭动”阶段配对数为164,ART受孕组结果异常率(32.3%)显著高于自然受孕组(18.9%)(χ²=8.30,P=0.008);“不安运动”阶段配对数为247,组间差异无统计学意义(P>0.05)。结论 ART可能增加了子代“早产/扭动”阶段结果异常的风险,其远期意义有待进一步研究。

关键词: 倾向性评分匹配, 辅助生殖技术, 子代, 全身运动评估

Abstract: Objective To explore the impact of the assisted reproductive technology (ART) on the offsprings′ general movement assessment (GMs) by applying propensity score matching . Method Infants who had received at least one time of GMs were collected in Minhang district from July 2015 to October 2017.Infants were divided into two groups of ART conceived and natural conceived.The first time of GMs results of the two groups during the two stages of “premature and twist” and “restless movement ” were matched by applying the one-to-one propensity score matching (PSM),setting the matching tolerance 0.000 03 and 0.000 15 respectively,with the gender,fetus number,birth weight,gestational age,the history of rescue,jaundice,brain and other disease,parental age,culture,occupation,maternal fetal miscarriage,medication,diabetes,or hypertension the history of other diseases as covariates.The differences between the two groups were compared. Results Before matched, the rate of abnormal result of two GMs stages in ART conceived group was significantly higher than that in natural conceived group(χ²=77.74,15.38,both P＜0.01).After matched,there were 164 pairs of data in the stage of premature and twist,and the rate of abnormal result of ART conceived group was significantly higher than that of natural conceived group (32.3% vs.18.9%,χ²=8.30,P=0.008).However,there was no significant difference between the two groups of 247 pairs of data in the stage of restless exercise (P>0.05). Conclusions ART may increase the risk of abnormal result in the stage of “premature and twist”,so further research is needed.

Key words: propensity score matching, assisted reproductive technology, offsprings, general movement assessment

中图分类号:

R179

姜春花, 肖丽萍, 黄俊, 李云, 杨红, 曹佳燕, 张莺, 钟平莉, 程紊, 张越. 运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响[J]. 中国儿童保健杂志, 2018, 26(10): 1068-1071.

JIANG Chun-hua, XIAO Li-ping, HUANG Jun, LI Yun, YANG Hong, CAO Jia-yan, ZHANG Ying, ZHONG Ping-li, CHENG Wen, ZHANG Yue. Impact of the assisted reproductive technology on the offsprings′ general movement assessment
by applying propensity score matching[J]. journal1, 2018, 26(10): 1068-1071.

0
/ / 推荐

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/10.11852/zgetbjzz2018-26-10-07

https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/Y2018/V26/I10/1068

[1]	金青青, 吕靖, 周节, 肖静, 方伟, 罗向红. 妊娠期睡眠剥夺对子代的影响[J]. 中国儿童保健杂志, 2023, 31(5): 512-515.
[2]	沈修姝, 汪军. 全身运动评估的临床应用研究进展[J]. 中国儿童保健杂志, 2023, 31(2): 167-170.
[3]	许钦雯, 徐旭娟, 俞洁, 茅欣欣. 孕期宫内血糖暴露对子代器官功能发育的影响[J]. 中国儿童保健杂志, 2022, 30(9): 985-988.
[4]	胡丹, 汪晓霞, 崔一帆, 刘璞, 梁倩, 肖绪武. 辅助生殖技术受孕单胎早产儿出生结局和认知发育的纵向研究[J]. 中国儿童保健杂志, 2022, 30(6): 669-672.
[5]	胡丹, 汪晓霞, 崔一帆, 刘璞, 梁倩, 肖绪武. 辅助生殖技术试管足月儿神经心理行为发育的纵向研究[J]. 中国儿童保健杂志, 2022, 30(2): 140-143.
[6]	刘亚璇, 段稳丽, 王银娟, 张一, 张茹, 金心韫, 徐发林. 辅助生殖技术受孕与自然受孕双胎早产儿临床特征比较分析[J]. 中国儿童保健杂志, 2021, 29(8): 834-837.
[7]	吴芙蓉, 梁树艺, 甘明霞. 全身运动评估指导极早和超早产儿早期干预的研究[J]. 中国儿童保健杂志, 2021, 29(4): 451-454.
[8]	张琳, 张园, 张丹, 李婧, 秦振英, 宋佳, 夏心如, 高莉, 崔毓桂, 胡幼芳, 刘嘉茵. 辅助生殖技术儿童体格和精神发育状况分析[J]. 中国儿童保健杂志, 2019, 27(8): 816-819.
[9]	侯杉杉, 杨洁. 妊娠期糖尿病母亲子代0~36月龄生长发育情况研究[J]. 中国儿童保健杂志, 2019, 27(7): 775-778.
[10]	肖平娟, 邵庆亮. 妊娠期糖尿病对子代肺成熟度影响的代谢组学研究进展[J]. 中国儿童保健杂志, 2019, 27(6): 617-619.
[11]	姜春花, 肖丽萍, 黄俊, 李云, 张莺, 钟平莉, 杨红, 苏怡, 骆丹丹. 运用倾向性评分匹配法探讨辅助生殖技术对子代1岁内PDMS评估结果的影响[J]. 中国儿童保健杂志, 2019, 27(5): 495-498.
[12]	宗璐, 吕晔, 张小雪, 张莉, 帖迎春. 宫内注射内毒素对早产子代大鼠学习记忆能力影响的研究[J]. 中国儿童保健杂志, 2019, 27(5): 503-506.
[13]	周雪, 李欣欣, 李可蒙, 贾飞勇, 李洪华. 不安运动阶段影响婴儿全身运动质量的影响因素分析[J]. 中国儿童保健杂志, 2019, 27(4): 436-439.
[14]	朱晓芸,何敏斯,陆春梅,尹欢欢,侍孝娟,朱默. 口腔运动干预对喂养困难早产儿进食能力的改善及影响因素研究[J]. 中国儿童保健杂志, 2019, 27(2): 142-145.
[15]	丁燕曙,郭海滨,韩光研,张琴芬,蒋佳佳. GMs评估技术对6月龄婴儿运动发育迟缓的预测研究[J]. 中国儿童保健杂志, 2018, 26(9): 1021-1024.

运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响

Impact of the assisted reproductive technology on the offsprings′ general movement assessment
by applying propensity score matching

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

运用倾向性评分匹配法探讨辅助生殖技术对子代全身运动评估结果的影响

Impact of the assisted reproductive technology on the offsprings′ general movement assessment by applying propensity score matching

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

Impact of the assisted reproductive technology on the offsprings′ general movement assessment
by applying propensity score matching