关键词: 高脂膳食, 尿酸, 黄嘌呤氧化酶, 腺苷脱氨酶

Abstract: Objective To explore the effect of perinatal high fat diet on uric acid metabolism in SD rat offspring. Methods Ten pregnant SD rats were randomly divided into control group and high fat diet group,fed with lab chow diet and high fat diet (containing 20% of lard) respectively.After weaning,half of male pups from either group were fed with lab chow and the other half were fed with high fat diet until 12 weeks of age.Then the body weight,level of serum uric acid,and activity of xanthine oxidase (XOD) and adenosine deaminase (ADA) were measured. Results The level of serum uric acid,the activity of XOD and body weight of the HF/HF group were higher than the B/B group and the HF/B group(P＜0.05).Compared with the B/B group,the level of serum uric acid and the activity of XOD were higher(P＜0.05).There was no difference of the activity of serum ADA among 4 groups. Conclusions Maternal high fat diet during gestation and lactation may cause hyperuricemia in rat SD offspring because of the increase of the activity of XOD.And the diet regulation on offspring after weaning can decrease the effect.

Key words: uric acid, high fat diet, xanthine oxidase, adenosine deaminase