Abstract: Objective To investigate the status of lactose intolerance among infants in Qinhuai District of Nanjing and the effects of different interventions,and to provid reference for fargeted inventions. Methods Healthy infants and diarrhea infants were tested by urinary galactose detection separately.Positive test results indicated lactase deficiency,which combined with gastrointestinal symptoms were suggested as lactose intolerance.Then analyze the different intervention results for the lactose intolerant infants. Results The incidence of lactase deficiency in infants with diarrhea was significantly higher than that of healthy children,the incidence of lactase deficiency in breast-fed infants with diarrhea was lower than that of formula-fed infants with diarrhea,the statistical differences of the two aspects were both significant(P＜0.05).The antidiarrheal time of the original milk diet plus lactase group and the lactose-free diet group were less than that of the continued original milk diet group.The differences between the former two and the latter group were significant respectively (P＜0.05).The former two had no statistical difference(P＞0.05). Conclusions Infants with diarrhea are prone to secondary lactose intolerance.The incidence of lactose intolerance in breast-fed infants is lower than that of formula-fed infants.The effects of keeping the original milk diet with lactase and the lactose-free diet to intervene the disease are both better than that of continuing the original milk diet,but has shortcomings in clinical application.Lactose intolerance impairs children's health,so early detection,early diagnosis and early targeted interventions are necessary.

Key words: lactose intolerance, lactase, lactose-free diet, infant

摘要： 目的 分析南京市秦淮区婴幼儿乳糖不耐受的现状及不同的干预效果,为针对性的干预治疗提供参考。方法 对健康和腹泻的婴幼儿分别采用尿半乳糖检测,结果阳性者为乳糖酶缺乏;合并胃肠道症状提示乳糖不耐受;并对乳糖不耐受儿童的不同干预结果进行分析。结果 腹泻婴幼儿乳糖酶缺乏检出率明显高于健康儿童,腹泻的母乳喂养儿乳糖酶缺乏检出率低于腹泻的人工喂养儿,差异均有统计学意义(P＜0.05)。继续原乳类饮食加服乳糖酶组与无乳糖饮食组的止泻时间均少于继续原乳类饮食组,差异均有统计学意义(P＜0.05);而前两者间差异无统计学意义(P＞0.05)。结论 婴幼儿腹泻易继发乳糖不耐受。母乳喂养儿乳糖不耐受检出率低于人工喂养儿。继续原乳类饮食加服乳糖酶与无乳糖饮食的干预效果均优于继续原乳类饮食,但临床应用各有缺点;乳糖不耐受影响儿童健康,需早发现、早诊断,并及早予以针对性地干预治疗。

关键词: 乳糖不耐受, 乳糖酶, 无乳糖饮食, 婴幼儿